- Orthanilic acid-promoted reverse turn formation in peptides
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Orthanilic acid (2-aminobenzenesulfonic acid, SAnt), an aromatic β-amino acid, has been shown to be highly useful in inducing a folded conformation in peptides. When incorporated into peptide sequences (Xaa- SAnt-Yaa), this rigid aromatic β-amino acid strongly imparts a reverse-turn conformation to the peptide backbone, featuring robust 11-membered-ring hydrogen-bonding.
- Kale, Sangram S.,Priya, Gowri,Kotmale, Amol S.,Gawade, Rupesh L.,Puranik, Vedavati G.,Rajamohanan,Sanjayan, Gangadhar J.
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supporting information
p. 2222 - 2224
(2013/03/29)
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