898785-47-2

Usage

General Description

2',3,3-Trimethylbutyrophenone, also known as TMB, is a chemical compound with the molecular formula C12H16O. It is an organic compound classified as a phenone, with a butyrophenone structure. TMB is commonly used as a flavoring agent in the food and beverage industry due to its pleasant and fruity odor. It is also used as a fragrance ingredient in perfumes and cosmetics. Furthermore, TMB has been studied for its potential applications in pharmaceuticals, particularly as an intermediate in the synthesis of various medications. Additionally, TMB has been investigated for its potential use as an insect repellent and in anti-fungal formulations. Overall, 2',3,3-Trimethylbutyrophenone has a wide range of industrial and commercial applications due to its distinctive odor and possible pharmaceutical and healthcare-related uses.

InChI:InChI=1/C13H18O/c1-10-7-5-6-8-11(10)12(14)9-13(2,3)4/h5-8H,9H2,1-4H3

Upstream product

• 615-37-2 ortho-methylphenyl iodide 
• 917-92-0 3,3-Dimethylbut-1-yne 

Relevant academic research and scientific papers

Iron(III)-Catalyzed Hydration of Unactivated Internal Alkynes in Weak Acidic Medium, under Lewis Acid-Assisted Br?nsted Acid Catalysis

Alkylarylalkynes are converted with full regioselectivity into the corresponding arylketones by formal hydration of the triple bond under weak acidic conditions, at times and temperatures (≤95 °C) comparable to those used for terminal alkynes. The process catalyzed by Fe2(SO4)3nH2O in glacial acetic acid exhibits good functional group compatibility, including that with bulky triple bond substituents, and can be extended to the one-pot transformation of aryltrimethylsilylacetylenes into acetyl derivatives via a desilylation-hydration sequence. The overall reactivity pattern along with proton affinity data indicate that the triple bond is activated by proton transfer rather than by π-interaction with the metal ion. This mechanistic feature, at variance with that of noble metal catalysts, accounts for the total regioselectivity and the insensitivity to steric hindrance exhibited by the Fe2(SO4)3nH2O/AcOH catalytic system. (Figure presented.).