- A vicarious, one-pot synthesis of benzo- and naphthofurans: Applications to the syntheses of stereumene B and paeoveitols
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An interesting albeit unexpected deviation during attempted Tanabe γ-lactone annulation on 4-hydroxycyclohexanones has led to a general, one-pot synthesis of benzofurans and naphtho[2,3–b]furans from readily assembled precursors. The utility of this adaptable methodology has been demonstrated through concise syntheses of natural products, stereumene B, paeoveitol D and (±)-paeoveitol.
- Rashid, Showkat,Bhat, Bilal A.,Mehta, Goverdhan
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supporting information
p. 1122 - 1125
(2019/03/26)
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- PYRAZOLE DERIVATIVES AS BROMODOMAIN INHIBITORS
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The present invention is directed to pyrazole derivatives, pharmaceutical compositions comprising the compounds and the use of the compounds or the compositions in the treatment of various diseases
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- Synthesis of Normorphans through an Efficient Intramolecular Carbamoylation of Ketones
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An unexpected C-C bond cleavage was observed in trichloroacetamide-tethered ketones under amine treatment and exploited to develop a new synthesis of normophans from 4-amidocyclohexanones. The reaction involves an unprecedented intramolecular haloform-typ
- Diaba, Fa?za,Montiel, Juan A.,Serban, Georgeta,Bonjoch, Josep
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supporting information
p. 3860 - 3863
(2015/08/18)
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- NOVEL TETRAHYDROISOQUINOLINE DERIVATIVE
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The present invention relates to a compound or a pharmacologically acceptable salt thereof having an excellent DGAT inhibitory effect and feeding suppressant effect. The present invention provides a compound represented by the general formula (I), or pharmacologically acceptable salt thereof: [wherein, R1 represents a phenylaminocarbonyl group that may be substituted with 1 to 5 group(s) independently selected from Substituent Group A, a benzoxazol-2-yl group that may be substituted with 1 to 3 group(s) independently selected from Substituent Group A, or the like; R2 independently represents a C1-C6 alkyl group; R3 represents a group represented by the formula -C(=O)-O-R4 or the like; R4 represents a hydrogen atom, a C1-C6 alkyl group that may be substituted with 1 to 3 group(s) independently selected from Substituent Group B, or the like; X represents an oxygen atom, a methylene group, or a group represented by the formula -NH-, or the like; L represents a single bond, a methylene group, or the like;...... represents a single bond or a double bond; m represents 1 or 2; n represents an integer of 0 to 5; Substituent Group A represents a halogen atom, a C1-C6 alkyl group, a C1-C6 halogenated alkyl group, a C1-C6 alkoxy group, or the like; and Substituent Group B represents a C3-C6 cycloalkyl group, a phenyl group, a carboxyl group, or the like].
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Page/Page column 33
(2010/12/29)
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- Process for the selective enzymatic hydroxylation of aldehydes and ketones
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A process for the selective enzymatic hydroxylation of aldehydes and ketones using chiral anchor-protective groups.
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- Chiral auxiliaries as docking/protecting groups: Biohydroxylation of selected ketones with Beauveria bassiana ATCC 7159
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The concept of chiral docking/protecting groups for biohydroxylation was extended from cyclopentanone to other ketones. Reaction of cyclohexanone, (R)-3-methylcyclohexanone, cycloheptanone, 5-methyl-2-hexanone and 4-methyl-2-pentanone with (R)-2-amino-1-propanol and subsequent in situ benzoylation afforded the corresponding N-benzoylated oxazolidine derivatives. All substrates were hydroxylated with the fungus Beauveria bassiana ATCC 7159, one of which was diastereoselectively hydroxylated with a d.e. of 99%. In this manner, access to the corresponding hydroxylated ketones was provided.
- De Raadt, Anna,Fetz, Barbara,Griengl, Herfried,Florian Klingler, Markus,Krenn, Birgit,Mereiter, Kurt,Franz Münzer, Dieter,Plachota, Peter,Weber, Hansj?rg,Saf, Robert
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p. 8151 - 8157
(2007/10/03)
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- EFFICIENT SYNTHESIS OF NATURAL ENANTIOMER OF SPOROGEN-AO 1 (13-DESOXYPHOMENONE), A SPOROGENIC SESQUITERPENE FROM ASPERGILLUS ORYZAE
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An efficient total synthesis of (+)-sporogen-AO 1 (13-desoxyphomenone) 1 was achieved in 20 steps from ethyl (1R,2S)-5,5-ethylenedioxy-2-hydroxycyclohexanecarboxylate 3 in 8.3percent overall yield.The optically active 3 with 98.4percent e.e. was easily ob
- Kitahara, Takeshi,Kurata, Hitoshi,Mori, Kenji
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p. 4339 - 4350
(2007/10/02)
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