899-79-6Relevant articles and documents
Zn-Mediated Hydrodeoxygenation of Tertiary Alkyl Oxalates
Ye, Yang,Ma, Guobin,Yao, Ken,Gong, Hegui
supporting information, p. 1625 - 1628 (2021/01/18)
Herein we describe a general, mild, and scalable method for hydrodeoxygenation of readily accessible tertiary alkyl oxalates by Zn/silane under Ni-catalyzed conditions. The reduction method is suitable for an array of structural motifs derived from tertiary alcohols that bear diverse functional groups, including the synthesis of a key intermediate en route to estrone.
Total synthesis preparation method of estrone
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Paragraph 0045-0048, (2020/02/19)
The invention relates to the technical field of bulk drug manufacturing, and particularly discloses a total synthesis preparation method of estrone. According to the preparation method, estrone is obtained by using tetralone as a starting raw material through seven chemical synthesis steps of Grignard reaction, hydrolysis, condensation, cyclization, ketal protection, hydrogenation and hydrolysis.According to the invention, the preparation method has characteristics of easily available raw materials, simple reaction route, mild reaction conditions, high stereoselectivity, low pollution, low cost and good application prospects.
Desymmetrization of cyclic 1,3-diketones via Ir-catalyzed hydrogenation: An efficient approach to cyclic hydroxy ketones with a chiral quaternary carbon
Gong, Quan,Wen, Jialin,Zhang, Xumu
, p. 6350 - 6353 (2019/07/04)
We herein report an efficient method to synthesize cyclic hydroxy ketones with a chiral quaternary center. Catalyzed by an Ir/f-ampha complex, cyclic α,α-disubstituted 1,3-diketones were hydrogenated, giving mono-reduced products with both high enantiosel
Catalytic asymmetric torgov cyclization: A concise total synthesis of (+)-estrone
Prevost, Sebastien,Dupre, Nathalie,Leutzsch, Markus,Wang, Qinggang,Wakchaure, Vijay,List, Benjamin
supporting information, p. 8770 - 8773 (2014/08/18)
An asymmetric Torgov cyclization, catalyzed by a novel, highly Bronsted acidic dinitro-substituted disulfonimide, is described. The reaction delivers the Torgov diene and various analogues with excellent yields and enantioselectivity. This method was applied in a very short synthesis of (+)-estrone.
Pentacyclic compounds by samarium diiodide-induced cascade cyclizations of naphthyl-substituted 1,3-diones
Wefelscheid, Ulrike K.,Reissig, Hans-Ulrich
supporting information; scheme or table, p. 65 - 69 (2009/04/06)
Treatment of naphthyl-substituted cyclopentane-1,3-diones with the samarium diiodidehexamethylphosphoramide (HMPA) complex in the presence of tert-butyl alcohol provided the expected tetracyclic diols with steroid-like structures. Surprisingly, reactions