89942-59-6

Basic information

• Product Name: 2-ACETONICOTINIC ACID
• Synonyms: 2-ACETONICOTINIC ACID;2-ACETYLNICOTINIC ACID;2-ANA;3-PYRIDINE CARBOXYLIC ACID, -2-ACETYL;2-ACTYL NICOTINIC ACID;3-Pyridinecarboxylic acid, 2-acetyl- (9CI)
• CAS NO: 89942-59-6
• Molecular Formula: C₈H₇NO₃
• Molecular Weight: 165.15
• Product Categories: ACETYLGROUP;API intermediates
• Mol File: 89942-59-6.mol

Chemical Properties

• Melting Point: 126-127 °C
• Boiling Point: 334.9±27.0 °C(Predicted)
• Appearance: /
• Density: 1.303±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 3.40±0.10(Predicted)
• CAS DataBase Reference: 2-ACETONICOTINIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 2-ACETONICOTINIC ACID(89942-59-6)
• EPA Substance Registry System: 2-ACETONICOTINIC ACID(89942-59-6)

Safety Data

• Hazardous Substances Data: 89942-59-6(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2-Acetonicotinic acid is used as an intermediate in the synthesis of various pharmaceuticals for its role in the production of anti-tuberculosis and anti-leprosy drugs. Its presence in these medications is crucial for their therapeutic effects against these specific diseases.
Used in Agrochemical Industry:
In the agrochemical sector, 2-Acetonicotinic acid serves as a building block in the creation of various agrochemicals. Its incorporation into these products is essential for enhancing crop protection and improving agricultural yields.
Used in Dye Industry:
2-Acetonicotinic acid is also utilized in the dye industry, where it contributes to the development of new dyes. Its chemical properties allow for the creation of dyes with unique characteristics, expanding the range of colorants available for various applications.

Upstream product

• 38070-71-2 4-aza-3-chloro-3-methyl-1(3H)-isobenzofuranone 
• 611-32-5 8-methylquinoline 
• 111068-02-1 3-acetoxy-4-aza-3-methyl-1(3H)-isobenzofuranone 
• 858431-39-7 hydroxy-(5-oxo-5,7-dihydro-furo[3,4-b]pyridin-7-yl)-acetic acid 
• 7732-18-5 water 
• 2398-81-4 Nicotinic acid N-oxide 
• 111068-01-0 3-acetoxy-4-aza-3-methyl-1(3H)-isobenzofuranone 4-oxide 
• 85320-78-1 2-acetylnicotinic acid 1-oxide 
• 38070-70-1 4-aza-3-chloro-3-methyl-1(3H)-isobenzofuranone 4-oxide 

Downstream Products

• 89-00-9 Pyridine-2,3-dicarboxylic acid 

Relevant articles and documents

Method for producing substituted pyridine-carboxylic acids

An improved process for the preparation of substituted pyridinecarboxylic acids (II), useful as herbicide intermediates, by ozonolysis of quinolines (I).

Substituted semi-carbazones and related compounds

Substituted semicarbazones, thiosemicarbazones and isothiosemicarbazones and salts thereof, intermediates therefor, synthesis thereof, and the use of said compounds for the control of weeds.

Ozonolysis of Quinolines: A Versatile Synthesis of Polyfunctional Pyridines

A simple, safe and efficient procedure, easily adapted to a large scale, is described for the synthesis of substituted quinolines 2, which are readily oxidized by ozone in the presence of mineral acid, followed by an oxidative work up with hydrogen peroxide to afford substituted 2,3-pyridinedicarboxylic acids 3a-d,f and acyl pyridines 3e, g.

REINVESTIGATION OF THE REACTION OF NICOTINIC ACID 1-OXIDE WITH ACETIC ANHYDRIDE

Reinvestigation of the reaction of nicotinic acid 1-oxide (1) with boiling acetic anhydride has revealed that the primary product is not 2-acetylnicotinic acid 1-oxide (3) but 3-acetoxy-4-aza-3-methyl-1(3H)-isobenzofuranone 4-oxide (2), the acetate of the ring tautomer of 3.Reactions of 2 and 3 with phosphorus trichloride and some related reactions are reported.