Synthesis and evaluation of novel E-2-(2-thienyl)- and Z-2-(3-thienyl)-3- arylacrylonitriles as antifungal and anticancer agents
A series of 3-aryl-2-(2-thienyl)acrylonitriles 7 and 3-aryl-2-(3-thienyl) acrylonitriles 8 were synthesized by the reaction of aromatic aldehydes 6 with 2- and 3-thienylacetonitriles 4 and 5, and evaluated for antifungal and cytotoxic activities against a