- HETEROCYCLIC GTP CYCLOHYDROLASE 1 INHIBITORS FOR THE TREATMENT OF PAIN
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The present invention relates to the field of small molecule heterocyclic inhibitors of GTP cyclohydrolase (GCH-I), or a tautomer, prodrug, or pharmaceutically acceptable salt thereof. The invention also features pharmaceutical compositions of the compounds and the medical use of these compounds for the treatment or prevention of pain (e.g., inflammatory pain, nociceptive pain, functional pain, or neuropathic pain).
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Page/Page column 57
(2011/04/19)
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- Molecular recognition of a thymine bulge by a high affinity, deazaguanine-based hydrogen-bonding ligand
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7-Deazaguanine (7-DeG) was developed as a hydrogen-bonding module capable of enhanced recognition of uracil (U) and thymine (T); a water-soluble derivative displayed high affinity and selectivity toward DNA and RNA duplexes containing single T- and U-bulg
- Ong, Hugo C.,Arambula, Jonathan F.,Rao Ramisetty, Sreenivasa,Baranger, Anne M.,Zimmerman, Steven C.
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supporting information; experimental part
p. 668 - 670
(2009/06/05)
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- Alkylpurines as immunopotentiating agents. Synthesis and antiviral activity of certain alkylguanines.
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Several simple 8-substituted 9-alkyl- and 7,8-disubstituted 9-alkylguanine derivatives were synthesized as potential antiviral agents. These were tested for antiviral protection against a lethal Semliki Forest virus (SFV) infection in mice, and their anti
- Michael,Cottam,Smee,Robins,Kini
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p. 3431 - 3436
(2007/10/02)
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