- The neuroprotective activity of GPE tripeptide analogues does not correlate with glutamate receptor binding affinity
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The influence of several modifications on the GPE tripeptide structure upon the binding to GluRs and on their neuroprotective effects has been studied. The results indicated that the prevention of neuronal death showed by GPE and some analogues is not dir
- Alonso De Diego, Sergio A.,Gutierrez-Rodriguez, Marta,Perez de Vega, M. Jesus,Gonzalez-Muniz, Rosario,Herranz, Rosario,Martin-Martinez, Mercedes,Cenarruzabeitia, Edurne,Frechilla, Diana,Rio, Joaquin Del,Jimeno, M. Luisa,Garcia-Lopez, M. Teresa
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p. 3396 - 3400
(2007/10/03)
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- Vanilloid receptor ligands and their use in treatments
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Compounds having the general structure and compositions containing them, for the treatment of acute, inflammatory and neuropathic pain, dental pain, general headache, migraine, cluster headache, mixed-vascular and non-vascular syndromes, tension headache, general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, inflammatory pain and associated hyperalgesia and allodynia, neuropathic pain and associated hyperalgesia and allodynia, diabetic neuropathy pain, causalgia, sympathetically maintained pain, deafferentation syndromes, asthma, epithelial tissue damage or dysfunction, herpes simplex, disturbances of visceral motility at respiratory, genitourinary, gastrointestinal or vascular regions, wounds, burns, allergic skin reactions, pruritus, vitiligo, general gastrointestinal disorders, gastric ulceration, duodenal ulcers, diarrhea, gastric lesions induced by necrotising agents, hair growth, vasomotor or allergic rhinitis, bronchial disorders or bladder disorders.
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Page/Page column 63
(2008/06/13)
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