- Benzothiazine derivatives and their applications as medicinal products or as synthesis intermediates for medicinal products
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The invention relates to the compounds corresponding to the general formula I STR1 in which: R1 represents a lower alkyl radical (having one to four carbon atoms), a phenyl radical or a benzyl radical. These compounds are useful as medicinal products or as synthesis intermediates for medicinal products.
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- Process for the preparation of oxazinobenzothiazine 6,6-dioxide derivatives
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The present invention relates to a process for the preparation of a 5-methyl-3-heteroaryl-2H,5H-1,3-oxazino[5,6-c] [1,2] benzothiazine-2,4-(3H)-dione 6,6-dioxide of the general formula I: STR1 in which R represents a heteroraryl radical, preferably substituted or unsubstituted pyrimidinyl or pyridyl, of the type consisting in reacting an amide of the general formula II: STR2 in which R1 represents a heteroarylamino radical, preferably substituted or unsubstituted pyrimidinylamino or pyridylamino, with a compound of the general formula III: STR3 in which R2 represents a C1 to C4 lower alkyl radical such as methyl or ethyl, an aryl radical such as phenyl, or an alkylaryl radical such as benzyl, wherein the reaction is carried out in an organic solvent selected from the group comprising pyridine, substituted pyridines such as 4-dimethylaminopyridine, 4-(pyrrolidin-1-yl)pyridine and 2,6-ditert.-butyl-4-methylpyridine, and mixtures thereof.
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- Derivatives of oxazinobenzothiazine-6,6-dioxide
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This invention relates to new derivatives of oxazinobenzothiazine-6,6-dioxide, to a process for the production thereof and to the use thereof as medicaments. The new derivatives according to the present invention correspond to the general formula I: STR1 wherein: R represents a linear or branched lower C1 -C4 alkyl radical, in particular the methyl and ethyl radicals, X represents an oxygen atom or a sulphur atom, and Het represents a mono- or bicyclic unsaturated heterocycle containing a nitrogen heteroatom in the ortho position relative to the link between the said heterocycle and the nitrogen atom of the oxazine ring, the said heterocycle optionally containing one or two other additional heteroatoms selected from nitrogen, oxygen and sulphur, and also being able to be substituted by one or two methyl radicals.
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