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9014-08-8

ENOLASE, also known as 2-phosphoglycerate hydratase, is a cytosolic metalloenzyme that plays a crucial role in glycolysis. It is encoded by three homologous genes in mammals and is found in archaea, bacteria, and eukaryotes. The enzyme from baker's yeast is a homodimer containing two bound Mg2+ ions and consists of 436 amino acids, with a single cysteine residue and a molecular weight of 93 kDa. Two of the active site components include His191 and Arg414. ENOLASE catalyzes the conversion of 2-phosphoglyceric acid to the phosphorylated enol of pyruvic acid.

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  • 9014-08-8 Structure

  • Basic information

    1. Product Name: ENOLASE
    2. Synonyms: 2-Phospho-D-glycerate hydro-lyase, Phosphopyruvate hydratase;Enolase from baker's yeast (S. cerevisiae),2-Phospho-D-glycerate hydro-lyase, Phosphopyruvate hydratase;Enolase, 2-phospho-D-glycerate hydro-lyase;Phosphopyruvate hydratase (from Yeast), 50% glycerol solution;ENOLASE;EC 4.2.1.11;EC: 4.2.1.11;2-PHOSPHO-D-GLYCERATE HYDRO-LYASE
    3. CAS NO:9014-08-8
    4. Molecular Formula: NULL
    5. Molecular Weight: 0
    6. EINECS: 232-754-3
    7. Product Categories: enzyme
    8. Mol File: 9014-08-8.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /lyophilized powder
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: 2-8°C
    8. Solubility: N/A
    9. CAS DataBase Reference: ENOLASE(CAS DataBase Reference)
    10. NIST Chemistry Reference: ENOLASE(9014-08-8)
    11. EPA Substance Registry System: ENOLASE(9014-08-8)

  • Safety Data

    1. Hazard Codes: B
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany: 3
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 9014-08-8(Hazardous Substances Data)

9014-08-8 Usage

Uses

Used in Research Applications:
ENOLASE is used as an antigen during enzyme-linked immunosorbent assay (ELISA) to identify and characterize autoantibodies against catalase and α-enolase in patients with primary sclerosing cholangitis. This helps in understanding the role of these autoantibodies in the disease and their potential as diagnostic markers.
Used in Protein Analysis:
ENOLASE has been used to study temperatureand denaturant-induced yeast enolase denaturation using Fourier transform infrared spectroscopy. This technique provides insights into the structural changes and stability of the enzyme under various conditions.
Used in Chromatofocusing-Mass Spectrometry:
ENOLASE, along with other proteins, has been used to study gradient chromatofocusing-mass spectrometry, a new technique for protein analysis. This method allows for the separation and identification of proteins based on their isoelectric points and molecular weights, providing valuable information for proteomics research.
Used in Pharmaceutical Industry:
ENOLASE is used as a target enzyme in the development of drugs that modulate its activity. This can have potential applications in the treatment of various diseases, such as cancer, by affecting the glycolytic pathway and energy metabolism in cells.
Used in Biotechnology:
ENOLASE can be used in biotechnological applications, such as the production of biofuels or the development of biosensors, by harnessing its enzymatic activity to catalyze specific reactions in a controlled manner.

Biochem/physiol Actions

Enolase plays a key role in glycolysis and gluconeogenesis. Enolase, found in the nucleus of mammalian cells plays a key role in transcriptional modulation of genes, which participates in morphological transformation and cell proliferation.

Check Digit Verification of cas no

The CAS Registry Mumber 9014-08-8 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 9,0,1 and 4 respectively; the second part has 2 digits, 0 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 9014-08:
(6*9)+(5*0)+(4*1)+(3*4)+(2*0)+(1*8)=78
78 % 10 = 8
So 9014-08-8 is a valid CAS Registry Number.

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