N-tetrazolyl beta-lactams of the Formula: and the pharmaceutically acceptable salts thereof wherein R2 is hydrogen, alkyl having 1 to 6 carbon atoms or carboalkoxy having 2 to 7 carbon atoms; and Z is and W is thus forming a zwitterion, or Z is wherein R1 is benzyl, phenyloxymethyl or wherein Y is alkoxy or substituted alkoxy having 1 to 6 carbon atoms wherein the substituent on the alkoxy group is --COOH; and W is wherein R3 is H, M or --CH2COOM, wherein M is a pharmaceutically acceptable cation are disclosed. The compounds are useful as antibiotics
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(2008/06/13)
THE SYNTHESIS OF N-(TETRAZOL-5-YL)AZETIDIN-2-ONES
A series of N-(tetrazol-5-yl)azetidin-2-ones have been prepared from serine and threonine and evaluated as antibiotics against a range of bacteria.
Andrus, Alex,Partridge, Beverly,Heck, James V.,Christensen, B. G.
p. 911 - 914
(2007/10/02)
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