90377-00-7

Basic information

• Product Name: L-a-Me-Val-NH2
• Synonyms: L-a-Me-Val-NH2;(S)-2-Amino-2,3-dimethylbutanamide
• CAS NO: 90377-00-7
• Molecular Formula: C₆H₁₄N₂O
• Molecular Weight: 130.18816
• Mol File: 90377-00-7.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: L-a-Me-Val-NH2(CAS DataBase Reference)
• NIST Chemistry Reference: L-a-Me-Val-NH2(90377-00-7)
• EPA Substance Registry System: L-a-Me-Val-NH2(90377-00-7)

Safety Data

• Hazardous Substances Data: 90377-00-7(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
L-a-Me-Val-NH2 is used as a key intermediate in the synthesis of various pharmaceuticals and chemical compounds. Its unique structure allows it to be a versatile building block for the development of new drugs and therapeutic agents.
Used in Asymmetric Catalysis:
L-a-Me-Val-NH2 is used to prepare dihydroimidazolonylpyridine, which acts as a chiral ligand in copper (II) or iron (III) complexes. These complexes are employed in asymmetric catalysis, a technique used to produce enantiomerically pure compounds, which are essential in the pharmaceutical industry for the development of single-enantiomer drugs with improved efficacy and reduced side effects.

Upstream product

• 563-80-4 3-methyl-butan-2-one 
• 13893-53-3 2-amino-2,3-dimethylbutyronitrile 
• 90376-99-1 (S)-2-amino-2,3-dimethylbutyronitrile 

Downstream Products

• 138142-01-5 (S)-4-isopropyl-4-methyl-oxazolidine-2,5-dione 
• 1291096-41-7 1-Cbz-N-((1S)-1-carbamoyl-1,2-dimethylpropyl)-(S)-prolinamide 
• 1276021-32-9 (S)-2-(2-bromophenyl)-4-isopropyl-1,4-dimethyl-4,5-dihydro-1H-imidazol-5-one 
• 1276021-33-0 (S)-2-(4-isopropyl-1,4-dimethyl-5-oxo-4,5-dihydro-1H-imidazol-2-yl)benzoic acid 
• 1276021-34-1 (S,S)-N,N'-bis(2-carbamoyl-3-methylbut-2-yl)-2-bromobenzene-1,3-dicarboxamide 
• 1276021-30-7 (S)-N-(2-carbamoyl-3-methylbut-2-yl)-2-bromobenzenecarboxamide 

Relevant articles and documents

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Process for the preparation of alpha-amino-alpha-methylcarboxylic acid amides and alpha-amino-alpha-cycloalkylcarboxylic acid amides

The invention relates to a process for the preparation of α-amino-α-methylcarboxylic acid amides and α-amino-α-cycloalkyl-carboxylic acid amides of the formula: where R1 represents alkyl, alkaryl, aryl, alkenyl, heteroalkyl or heteroaryl, whether or not substituted, R2 is methyl, or forms, together with R1, a cycloalkyl group, by conversion of the corresponding amino nitriles using hydrogen peroxide under basic con-ditions and is characterized in that the conversion takes place in the presence of ammonia. By preference 2-6 moles hydrogen peroxide and 3-12 moles ammonia are used per mole amino nitrile.