905586-69-8

Basic information

• Product Name: 5-Fluoro-2-[[(1S)-1-(4-fluorophenyl)ethyl]amino]-6-[(5-methyl-1H-pyrazol-3-yl)amino]-3-pyridinecarbonitrile
• Synonyms: 5-Fluoro-2-[[(1S)-1-(4-fluorophenyl)ethyl]amino]-6-[(5-methyl-1H-pyrazol-3-yl)amino]-3-pyridinecarbonitrile;AZ 960;(S)-5-fluoro-2-(1-(4-fluorophenyl)ethylaMino)-6-(5-Methyl-1H-pyrazol-3-ylaMino)nicotinonitrile;5-Fluoro-2-[[(1S)-1-(4-fluorophenyl)ethyl]amino]-6-[(5-methyl-1H-pyrazol-3-yl)amino]-3-pyridinecarbonitrile AZ 960;(S)-5-Fluoro-2-((1-(4-fluorophenyl)ethyl)amino)-6-((5-methyl-1H-pyrazol-3-yl)amino)nicotinonit
• CAS NO: 905586-69-8
• Molecular Formula: C18H16F2N6
• Molecular Weight: 354.36
• Product Categories: A JAK2 kinase inhibitor.;Inhibitor;Inhibitors;JAK;STAT
• Mol File: 905586-69-8.mol

Chemical Properties

• Boiling Point: 515.2±50.0 °C(Predicted)
• Appearance: /
• Density: 1.37±0.1 g/cm3(Predicted)
• Solubility: Soluble in DMSO
• PKA: 13.42±0.10(Predicted)
• CAS DataBase Reference: 5-Fluoro-2-[[(1S)-1-(4-fluorophenyl)ethyl]amino]-6-[(5-methyl-1H-pyrazol-3-yl)amino]-3-pyridinecarbonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Fluoro-2-[[(1S)-1-(4-fluorophenyl)ethyl]amino]-6-[(5-methyl-1H-pyrazol-3-yl)amino]-3-pyridinecarbonitrile(905586-69-8)
• EPA Substance Registry System: 5-Fluoro-2-[[(1S)-1-(4-fluorophenyl)ethyl]amino]-6-[(5-methyl-1H-pyrazol-3-yl)amino]-3-pyridinecarbonitrile(905586-69-8)

Safety Data

• Hazardous Substances Data: 905586-69-8(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
AZ 960 is used as a JAK2 inhibitor for the treatment of myeloproliferative diseases, which have been linked to a mutation in JAK2 where a switch from valine to phenylalanine occurs at the 617 position (V617F). By inhibiting JAK2, AZ 960 can potentially reduce the aggressive nature of these diseases.
Used in Oncology Research:
AZ 960 is used as a research tool in oncology to study the role of JAK2 signaling pathway in aggressive adult T cell leukemia/lymphoma. Its ability to decrease STAT3/5 phosphorylation and inhibit cell proliferation in certain cell lines makes it a valuable compound for understanding the mechanisms of JAK2-related cancers.
Used in Drug Development:
AZ 960 is used in the development of new drugs targeting JAK2 for the treatment of various cancers and myeloproliferative diseases. Its high potency and selectivity for JAK2 make it a promising candidate for further research and development.
Used in Drug Screening:
AZ 960 can be used in drug screening assays to identify other potential JAK2 inhibitors or to study the effects of different compounds on JAK2 activity. This can help in the discovery of new drugs with improved efficacy and safety profiles.
Used in Preclinical Studies:
AZ 960 can be used in preclinical studies to evaluate its efficacy and safety in animal models of JAK2-related diseases. This can provide valuable information on the potential therapeutic benefits and side effects of AZ 960 before it proceeds to clinical trials.

Upstream product

• 905587-21-5 2,5-difluoro-6-(5-methyl-1H-pyrazol-3-ylamino)nicotinonitrile 
• 66399-30-2 (S)-1-(4-Fluoro-phenyl)-ethylamine 
• 321318-42-7 (S)-1-(4-fluorophenyl)ethan-1-aminium chloride 

Relevant articles and documents

In vitro and in vivo evaluation of 6-aminopyrazolyl-pyridine-3- carbonitriles as JAK2 kinase inhibitors

Synthesis and biological evaluation of a series of 6-aminopyrazolyl- pyridine-3-carbonitriles as JAK2 kinase inhibitors was reported. Biochemical screening, followed by profile optimization, resulted in JAK2 inhibitors exhibiting good kinase selectivity, pharmacokinetic properties, physical properties and pharmacodynamic effects.

PYRAZOLYLAMINOPYRIDINE DERIVATIVES USEFUL AS KINASE INHIBITORS

This invention relates to novel compounds having the Formula (I) to their pharmaceutical compositions and to their methods of use. These novel compounds provide a treatment for cancer.