- Benzothiazole, thiazolopyridine, benzooxazole and oxazolopyridine derivatives
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This invention is concerned with compounds of the formula wherein A, B1, B2, R1, R2 and G are as defined in the description and claims, and pharmaceutically acceptable salts thereof. The invention further relates to pharmaceutical compositions containing such compounds, to a process for their preparation and to their use for the treatment and/or prevention of diseases which are associated with the modulation of SST receptors subtype 5.
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Page/Page column 40
(2010/11/23)
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- Dose-dependent antithrombotic activity of an orally active tissue factor/factor VIIa inhibitor without concomitant enhancement of bleeding propensity
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The discovery of a highly potent and selective tissue factor/factor VIIa inhibitor is described. Upon oral administration of its double prodrug in the guinea pig, a dose-dependent antithrombotic effect is observed in an established model of arterial throm
- Zbinden, Katrin Groebke,Banner, David W.,Hilpert, Kurt,Himber, Jacques,Lave, Thierry,Riederer, Markus A.,Stahl, Martin,Tschopp, Thomas B.,Obst-Sander, Ulrike
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p. 5357 - 5369
(2008/02/07)
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- Selective and orally bioavailable phenylglycine tissue factor/factor VIIa inhibitors
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We describe the structure-based design and synthesis of highly potent, orally bioavailable tissue factor/factor VIIa inhibitors which interfere with the coagulation cascade by selective inhibition of the extrinsic pathway.
- Zbinden, Katrin Groebke,Obst-Sander, Ulrike,Hilpert, Kurt,Kuehne, Holger,Banner, David W.,Boehm, Hans-Joachim,Stahl, Martin,Ackermann, Jean,Alig, Leo,Weber, Lutz,Wessel, Hans Peter,Riederer, Markus A.,Tschopp, Thomas B.,Lave, Thierry
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p. 5344 - 5352
(2007/10/03)
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