Quantitative analysis of structure-activity relationship in the acridine serie part 1: Antiparasitic 9-thioaryl-acridine derivatives
Synthesis and antiparasitic activity vs T. cruzi and L. donovani of a series of 9-thioaryl acridines are reported. A convenient correlation between molecular structure and biological activity is proposed. Results not only agree with the classical interactions of acridines with DNA but also suggest possible role of charge transfer complexes.
Mrozek,Karolak-Wojciechowska,Bsiri,Barbe
p. 345 - 351
(2007/10/03)
Structure-trypanodical activity relationships
A set of 9-thioalkylacridinones, has been prepared and investigated' in vitro' against T. cruzi. Structure-antiparasitic activity relationships are detailed with a view to identify the major structural parameters for the activity under consideration.