Functional-group-tolerant catalytic migratory oxidative coupling of nitrones
A copper-catalyzed migratory oxidative-coupling reaction between nitrones and various ethers/amines exhibited high functional-group tolerance. Even in aqueous media, the reaction proceeded efficiently. For practical use of this catalysis, a unique sequent
Hashizume, Shogo,Oisaki, Kounosuke,Kanai, Motomu
supporting information
p. 2600 - 2606,7
(2020/09/02)
Catalytic migratory oxidative coupling of nitrones
A Cu(I)-catalyzed migratory oxidative coupling between nitrones and heterocycles or a methylamine is described. Selective C-C bond-formation proceeds through cleavage of two C(sp3)-H bonds concomitant with C=N double bond-migration. The reaction provides an alternating nitrone moiety, allowing for further synthetically useful transformations. Radical clock studies suggest that the nucleophilic addition of nitrones to an oxidatively generated carbocation is a key step.
Hashizume, Shogo,Oisaki, Kounosuke,Kanai, Motomu
supporting information; experimental part
p. 4288 - 4291
(2011/10/09)
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