Simplified cyclic analogues of bastadin-5. Structure-activity relationships for modulation of the RyR1/FKBP12 Ca2+ channel complex
Bastadin-5, a brominated macrodilactam from the marine sponge Ianthella basta, enhances release of Ca2+ from stores within the sarcoplasmic reticulum (SR) of muscle and nonmuscle cells by modulating RyR1/FKBP12 complex. Analogues of bastadin-5
Masuno, Makoto N.,Pessah, Isaac N.,Olmstead, Marilyn M.,Molinski, Tadeusz F.