908355-84-0

Basic information

• Product Name: 7-chlorothiazolo[4,5-c]pyridine-2-thiol
• Synonyms: 7-chlorothiazolo[4,5-c]pyridine-2-thiol;7-chloro-[1,3]thiazolo[4,5-c]pyridine-2-thiol;7-chlorothiazolo[4,5-c]pyridine-2(3H)-thione
• CAS NO: 908355-84-0
• Molecular Formula: C₆H₃ClN₂S₂
• Molecular Weight: 202.68
• Product Categories: CHIRAL CHEMICALS
• Mol File: 908355-84-0.mol

Chemical Properties

• Boiling Point: 346.175°C at 760 mmHg
• Flash Point: 163.161°C
• Appearance: /
• Density: 1.712g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.803
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 7-chlorothiazolo[4,5-c]pyridine-2-thiol(CAS DataBase Reference)
• NIST Chemistry Reference: 7-chlorothiazolo[4,5-c]pyridine-2-thiol(908355-84-0)
• EPA Substance Registry System: 7-chlorothiazolo[4,5-c]pyridine-2-thiol(908355-84-0)

Safety Data

• Hazardous Substances Data: 908355-84-0(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
7-chlorothiazolo[4,5-c]pyridine-2-thiol is used as a chemical intermediate for the synthesis of pharmaceutical compounds. Its unique molecular structure allows for the creation of new drug molecules with potential therapeutic applications.
Used in Chemical Research:
In the field of chemical research, 7-chlorothiazolo[4,5-c]pyridine-2-thiol serves as a valuable compound for studying the properties and reactions of thiazolopyridine derivatives, contributing to the advancement of organic chemistry.
Used in Material Science:
7-chlorothiazolo[4,5-c]pyridine-2-thiol is used as a building block in the development of new materials with specific properties, such as novel polymers or advanced materials with potential applications in various industries.
Used in Agrochemical Industry:
7-chlorothiazolo[4,5-c]pyridine-2-thiol is employed as an intermediate in the production of agrochemicals, such as pesticides or herbicides, where its unique chemical structure may contribute to the development of more effective and targeted products.
Used in Dye and Pigment Industry:
In the dye and pigment industry, 7-chlorothiazolo[4,5-c]pyridine-2-thiol is used as a precursor for the synthesis of new dyes and pigments, potentially leading to the creation of colors with improved properties, such as higher stability or brighter shades.

InChI:InChI=1/C6H3ClN2S2/c7-3-1-8-2-4-5(3)11-6(10)9-4/h1-2H,(H,9,10)

Upstream product

• 5435-54-1 4-hydroxy-3-nitropyridine 

Relevant articles and documents

7′-Substituted benzothiazolothio- and pyridinothiazolothio-purines as potent heat shock protein 90 inhibitors

We report on the discovery of benzo- and pyridinothiazolothiopurines as potent heat shock protein 90 inhibitors. The benzothiazole moiety is exceptionally sensitive to substitutions on the aromatic ring with a 7′-substituent essential for activity. Some of these compounds exhibit low nanomolar inhibition activity in a Her-2 degradation assay (28-150 nM), good aqueous solubility, and oral bioavailability profiles in mice. In vivo efficacy experiments demonstrate that compounds of this class inhibit tumor growth in an N87 human colon cancer xenograft model via oral administration as shown with compound 37 (8-(7-chloro-benzothiazol-2-ylsulfanyl)-9-(2-cyclopropylamino-ethyl) -9H-purin-6-ylamine).