909010-86-2Relevant articles and documents
ORGANIC COMPOUNDS
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Page/Page column 21, (2009/07/03)
The present invention provides heterocyclic derivatives that modulate the activity of stearoyl-CoA desaturase. Methods of using such derivatives to modulate the activity of stearoyl-CoA desaturase and pharmaceutical compositions comprising such derivatives are also encompassed.
2-SUBSTITUTED 5-MEMBERED HETEROCYCLES AS SCD INHIBITORS
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Page/Page column 80, (2008/12/06)
The present invention provides heterocyclic derivatives that modulate the activity of stearoyl-CoA desaturase. Methods of using such derivatives to modulate the activity of stearoyl-CoA desaturase and pharmaceutical compositions comprising such derivatives are also encompassed
Novel thienopyridine compounds, and methods of use thereof
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Page/Page column 28, (2008/06/13)
The present invention relates to novel compounds capable of modulating the stability and/or activity of hypoxia inducible factor (HIF).
Convergent processes for the synthesis of a GARFT inhibitor containing a methyl substituted thiophene core and intermediates therefor
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Page 13, (2010/02/10)
The invention relates to processes for the preparation of a GARFT inhibitor containing a methyl substituted thiophene core having the following structure: wherein each of R1 and R2 are independently a hydrogen atom or a moiety that together with the attached CO2 forms a readily hydrolyzable ester group; from an intermediate of the formula wherein R3 is a moiety that together with the attached CO2 forms a readily hydrolyzable ester group; Pg1 is an amino protecting group; R4 is H; or Pg1 can optionally be taken together with R4 and the nitrogen to which Pg1 and R4 are attached to form (i) an imine; or (ii) a fused or bridged bicyclic ring or a spirocyclic ring, wherein said ring is saturated and contains from 5 to 12 carbon atoms in which up to 2 carbon atoms are optionally replaced with a hetero moiety selected from O, S(O)j wherein j is an integer from 0 to 2, and —NR8—, provided that two O atoms, two S(O)j moieties, or an O atom and a S(O)j moiety are not attached directly to each other; R5 is selected from the group consisting of —C≡C— and —CH═CH—; and R8 is independently H or C1-C6 alkyl; to form the compound of the formula (I) that is optically pure; and to processes for preparing intermediates thereof.