Synthesis and biological characterization of B-ring amino analogues of potent benzothiadiazine hepatitis C virus polymerase inhibitors
Benzothiadiazine inhibitors of the HCV NS5B RNA-dependent RNA polymerase are an important class of non-nucleoside inhibitors that have received considerable attention in the search for novel HCV therapeutics. Research in our laboratories has identified a
Randolph, John T.,Flentge, Charles A.,Huang, Peggy P.,Hutchinson, Douglas K.,Klein, Larry L.,Lim, Hock B.,Mondal, Rubina,Reisch, Thomas,Montgomery, Debra A.,Jiang, Wen W.,Masse, Sherie V.,Hernandez, Lisa E.,Henry, Rodger F.,Liu, Yaya,Koev, Gennadiy,Kati, Warren M.,Stewart, Kent D.,Beno, David W. A.,Molla, Akhteruzzaman,Kempf, Dale J.