cas 909106-97-4, A 924825 | Articles data

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Synthesis and biological characterization of B-ring amino analogues of potent benzothiadiazine hepatitis C virus polymerase inhibitors
Benzothiadiazine inhibitors of the HCV NS5B RNA-dependent RNA polymerase are an important class of non-nucleoside inhibitors that have received considerable attention in the search for novel HCV therapeutics. Research in our laboratories has identified a
Randolph, John T.,Flentge, Charles A.,Huang, Peggy P.,Hutchinson, Douglas K.,Klein, Larry L.,Lim, Hock B.,Mondal, Rubina,Reisch, Thomas,Montgomery, Debra A.,Jiang, Wen W.,Masse, Sherie V.,Hernandez, Lisa E.,Henry, Rodger F.,Liu, Yaya,Koev, Gennadiy,Kati, Warren M.,Stewart, Kent D.,Beno, David W. A.,Molla, Akhteruzzaman,Kempf, Dale J.
supporting information; experimental part
p. 3174 - 3183
(2010/03/31)

THIADIAZINE DERIVATIVES USEFUL AS ANTI-INFECTIVE AGENTS
Compounds having the formula (I) are hepatitis C (HCV) polymerase inhibitors. Also disclosed are compositions and methods for inhibiting hepatitis C (HCV) polymerase, processes for making the compounds, and synthetic intermediates employed in the processe
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Page/Page column 147-148

(2008/06/13)