909534-11-8Relevant articles and documents
Method for preparing intermediate of chiral vicinal diamine
-
Paragraph 0034; 0035; 0036; 0039, (2019/01/06)
The invention discloses a method for preparing an intermediate of chiral vicinal diamine. The method comprises the following steps: adding a compound IV into a solvent, stirring the compound IV and the solvent in an ice water bath, adding an initiator into the obtained reaction system, adding a reducing agent into the reaction system in batches, heating the reaction system to 20-80 DEG C, and stirring the reaction system; and extracting the reaction system after the reaction is completed, drying the obtained organic phase, filtering the dried organic phase, and performing rotary drying to obtain a compound V that is the intermediate. The preparation method of the invention has the advantages of simplicity and mild reaction conditions, and can be widely applied to industrial production.
Hydrogen bonding makes a difference in the rhodium-catalyzed enantioselective hydrogenation using monodentate phosphoramidites
Liu, Yan,Sandoval, Christian A.,Yamaguchi, Yoshiki,Zhang, Xue,Wang, Zheng,Kato, Koichi,Ding, Kuiling
, p. 14212 - 14213 (2008/02/09)
A new generation of monodentate phosphoramidite ligands bearing a primary amine moiety was found to display comparable or better efficiency than bisphosphines in the Rh-catalyzed asymmetric hydrogenation of challenging substrates, such as (Z)-methyl α-ace