909698-10-8

Basic information

• Product Name: 4-cyclopropyl-2-methylbenzoic acid
• Synonyms: 4-cyclopropyl-2-methylbenzoic acid
• CAS NO: 909698-10-8
• Molecular Formula: C₁₁H₁₂O₂
• Molecular Weight: 176.21178
• Mol File: 909698-10-8.mol

Chemical Properties

• Appearance: /
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 4-cyclopropyl-2-methylbenzoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 4-cyclopropyl-2-methylbenzoic acid(909698-10-8)
• EPA Substance Registry System: 4-cyclopropyl-2-methylbenzoic acid(909698-10-8)

Safety Data

• Hazardous Substances Data: 909698-10-8(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Development:
4-cyclopropyl-2-methylbenzoic acid is used as an intermediate in the synthesis of various pharmaceuticals. Its unique structure allows it to be a key component in the development of new drugs with potential therapeutic benefits.
Used in Research:
4-cyclopropyl-2-methylbenzoic acid is used as a research compound for studying its potential biological activities, such as anti-inflammatory and anticancer properties. This helps in understanding its mechanism of action and potential applications in medicine.
Used in Chemical Synthesis:
4-cyclopropyl-2-methylbenzoic acid is used as a building block in the synthesis of complex organic molecules. Its unique structure makes it a valuable component in the creation of new chemical entities with diverse applications.
Used in the Pharmaceutical Industry:
4-cyclopropyl-2-methylbenzoic acid is used as a key component in the development of new drugs, thanks to its potential biological activities and unique structure. This makes it a valuable asset in the pharmaceutical industry for creating innovative and effective treatments.
Used in the Chemical Industry:
4-cyclopropyl-2-methylbenzoic acid is used in the chemical industry as a building block for synthesizing complex organic molecules. Its unique structure allows for the creation of new chemical entities with a wide range of applications.

Upstream product

• 909698-09-5 methyl 4-cyclopropyl-2-methylbenzoate 
• 68837-59-2 4-bromo-2-methylbenzoic acid 
• 99548-55-7 4-bromo-2-methyl-benzoic acid methyl ester 

Downstream Products

• 1198765-13-7 4-cyclopropyl-2-methylbenzoyl chloride 
• 1198765-14-8 N-(3-bromo-2-(((tert-butyldimethylsilyl)oxy)methyl)phenyl)-4-cyclopropyl-2-methylbenzamide 
• 1198765-15-9 2-(3-bromo-2-{[(tert-butyldimethylsilyl)oxy]methyl}phenyl)-6-cyclopropyl-3-hydroxy-3,4-dihydro-2H-isoquinolin-1-one 
• 1198765-16-0 2-[3-bromo-2-(tert-butyldimethylsilanyloxymethyl)phenyl]-6-cyclopropyl-2H-isoquinolin-1-one 

Relevant articles and documents

Structure-based drug design of RN486, a potent and selective Bruton's tyrosine kinase (BTK) inhibitor, for the treatment of rheumatoid arthritis

Structure-based drug design was used to guide the optimization of a series of selective BTK inhibitors as potential treatments for Rheumatoid arthritis. Highlights include the introduction of a benzyl alcohol group and a fluorine substitution, each of which resulted in over 10-fold increase in activity. Concurrent optimization of drug-like properties led to compound 1 (RN486) (J. Pharmacol. Exp. Ther. 2012, 341, 90), which was selected for advanced preclinical characterization based on its favorable properties.

SUBSTITUTED 1H-PYRROLOPYRIDINONE DERIVATIVES AS KINASE INHIBITORS

The present invention provides novel substituted 1H-Pyrrolopyridinone derivatives of formula (1) as protein kinase inhibitors, in which R1, R2, R3, R4, R5, R6 and 'p' have the meanings given in the specification, and pharmaceutically acceptable salts thereof that are useful in the treatment and prevention in diseases or disorder, in particular their use in diseases or disorder where there is an advantage in inhibiting kinase enzyme, more particularly BTK enzyme. The present invention also provides methods for synthesizing and administering the kinase inhibitor compounds. The present invention also provides pharmaceutical formulations comprising at least one of the kinase inhibitor compounds together with a pharmaceutically acceptable carrier, diluent or excipient therefor.

Inhibitors of Bruton's Tyrosine Kinase

This application discloses 5-phenyl-1H-pyridin-2-one, 6-phenyl-2H-pyridazin-3-one, and 5-Phenyl-1H-pyrazin-2-one derivatives according to generic Formulae I-III: wherein, variables Q, R, X, X′, Y1, Y2, Y2′, Y3, Y4, Y5, m, and n are defined as described herein, which inhibit Btk. The compounds disclosed herein are useful to modulate the activity of Btk and treat diseases associated with excessive Btk activity. The compounds are further useful to treat inflammatory and auto immune diseases associated with aberrant B-cell proliferation such as rheumatoid arthritis. Also disclosed are compositions containing compounds of Formulae I-III and at least one carrier, diluent or excipient.

Amide derivatives as ion-channel ligands and pharmaceutical compositions and methods of using the same

Compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, traumatic injury, and others.