- Self-Assembly of a Purely Covalent Cage with Homochirality by Imine Formation in Water
-
Self-assembly of host molecules in aqueous media via metal–ligand coordination is well developed. However, the preparation of purely covalent counterparts in water has remained a formidable task. An anionic tetrahedron cage was successfully self-assembled
- Cao, Xiaoyu,Chen, Binbin,Chen, Yixin,Ge, Chenqi,Jiao, Tianyu,Li, Hao,Li, Yintao,Liang, Lixin,Qu, Hang,Wang, Qi,Wu, Guangcheng,Zeng, Xiuqiong,Zhang, Chi
-
supporting information
p. 18815 - 18820
(2021/07/19)
-
- Indoline compound and application thereof
-
The invention discloses an indoline compound which has a structure as shown in formula (I), wherein in the formula (I), R1 is C1-C12 alkyl or C1-C12 alkoxy or C4-C20 heterocyclic radical, and heteroatom of the heterocyclic radical is N, S or O; and R2 is
- -
-
Paragraph 0024; 0025; 0026
(2018/04/28)
-
- Substituted heterocyclic compound, and use method and use thereof
-
The invention relates to a substituted heterocyclic compound, and a use method and a use thereof. The substituted heterocyclic compound and a medicinal composition including the compound can be used to depress orexin receptors, especially an orexin-1 rece
- -
-
Paragraph 0739; 0740; 0741; 0742; 0743
(2016/10/08)
-
- Formation of Benzo[ b ]Thiophenes by Electroreduction of Tert-Alkanecarbodithioates
-
The electroreduction of a 1:1-mixture of 2-bromobenzyl 2,2-dimethylpropanedithioate and 2-bromo-5-methylbenzyl 2,2-dimethylbutanedithioate led to a mixture of 2-Tert-butylbenzo[b]thiophene, 2-Tert-Amylbenzo[b]thiophene, 2-Tert-butyl-5-methylbenzo[b]thioph
- Voss, Jürgen,Dannat, Volker
-
p. 2142 - 2153
(2015/12/20)
-
- Selenium-catalyzed C(sp3)-H acyloxylation: Application in the expedient synthesis of isobenzofuranones
-
Oxidative Se-catalyzed C(sp3)-H bond acyloxylation has been used to construct a diverse array of isobenzofuranones from simple ortho-allyl benzoic acid derivatives. The synthetic procedure employs mild reaction conditions and gives high chemoselectivity enabled by an inexpensive organodiselane catalyst. The presented approach offers a new synthetic pathway toward the core structures of phthalide natural products.
- Kr?tzschmar, Felix,Kassel, Martin,Delony, Daniel,Breder, Alexander
-
supporting information
p. 7030 - 7034
(2015/05/05)
-
- NOVEL AMINE DERIVATIVE OR SALT THEREOF
-
A novel amine derivative expressed by general formula (1) (in the formula: G1, G2, and G3 are the same or different and represent CH or a nitrogen atom; R1 represents a chlorine atom, an optionally-substituted C3-8 cycloalkyl group, or the like; R2 represents -COOR5 (in the formula, R5 represents a hydrogen atom or a carboxyl protective group), or the like; R3 represents a hydrogen atom, or the like; and R4 represents an optionally-substituted condensed bicyclic hydrocarbon group, an optionally-substituted bicyclic heterocyclic group, or the like), or a salt thereof is useful in procedures such as the treatment or prevention of conditions related to excessive keratinocyte proliferation.
- -
-
Paragraph 1250-1252
(2015/11/11)
-
- CuCl-catalyzed one-pot synthesis of 5,6-dihydropyrazolo[1,5-c]quinazolines
-
A simple and efficient procedure for the preparation of 5,6-dihydropyrazolo[1,5-c]quinazolines via CuCl-catalyzed tandem reaction of 5-(2-bromoaryl)-1H-pyrazoles with aldehydes and aqueous ammonia under nitrogen atmosphere has been developed. The usefulne
- Guo, Shenghai,Wang, Jiliang,Li, Yan,Fan, Xuesen
-
p. 2383 - 2388
(2014/04/03)
-
- Supramolecular control of selectivity in hydroformylation of vinyl arenes: Easy access to valuable β-aldehyde intermediates
-
Go against the flow! A rationally designed regioselective hydroformylation catalyst, [Rh/L], in which noncovalent ligand-substrate interactions allow the unprecedented reversal of selectivity from the typical α-aldehyde to the otherwise unfavored product β-aldehyde, is reported. This catalytic system opens up novel and sustainable synthetic pathways to important intermediates for the fine-chemicals industry.
- Dydio, Pawel,Reek, Joost N. H.
-
supporting information
p. 3878 - 3882
(2013/05/09)
-
- NOVEL COMPOUNDS AND THEIR USE IN THERAPY
-
The present invention relates to novel chemical compounds formula (I) (C)n-B-(A)m-B-(C)n (I) wherein m is 0 or 1, and n is independently 0, 1, 2 or 3, A, each B and each C are independently selected from phenylene and five-and six-membered heteroaromatic rings, and for a terminal ring B or C also from bicyclic heteroaromatic fused rings having seven to ten ring members, wherein the bond between at least two of the rings A to C may be replaced by a carbonyl group (-CO-), wherein at least two of the rings A to C are substituted with one or two groups R, and wherein each ring A to C further optionally is substituted with one or two groups R1. The compounds are useful in therapy, especially therapy of a mammal suffering from a disease involving misfolded or aggregated forms of proteins.
- -
-
Page/Page column 90; 91
(2013/03/26)
-
- NOVEL THIOPHENE COMPOUNDS AND METHOD FOR IN VIVO IMAGING
-
The present invention relates to novel labelled compounds of formula (I) (C)n-B-(A)m-B-(C)n (I) wherein m is 0 or 1, and n is independently 0, 1, 2 or 3, A, each B and each C are independently selected from phenylene and five- and six-membered heteroaromatic rings, and for a terminal ring B or C also from bicyclic heteroaromatic fused rings having seven to ten ring members, wherein the bond between at least two of the rings A to C may be replaced by a carbonyl group ( -CO- ), wherein at least two of the rings A to C are substituted with one or two groups R, and wherein each ring A to C further optionally is substituted with one or two groups R1, for use in imaging amyloid deposits and aggregated protein in living patients. The invention further relates to imaging methods using labelled or unlabelled compounds of formual I and the use of unlabelled compounds in such methods.
- -
-
Page/Page column 95
(2013/03/26)
-
- BORON-CONTAINING SMALL MOLECULES
-
This invention provides novel compounds, methods of using the compounds, and pharmaceutical formulations comprising the compounds.
- -
-
Paragraph 0199
(2013/06/04)
-
- Design, synthesis and identification of novel colchicine-derived immunosuppressant
-
Synthesis and biological evaluation of various colchicine analogues through the mixed-lymphocyte reaction (MLR), lymphoproliferation, and inhibitory effects on the inflammatory genes are described. In addition, a new series of immunosuppressive agents developed on the structural basis of colchicine, as well as their structure-activity relationships is reported. The most potent analogue 20a exhibited an excellent immunosuppressive activity on in vivo skin-allograft model, which is comparable to that of cyclosporin A.
- Chang, Dong-Jo,Yoon, Eun-Young,Lee, Geon-Bong,Kim, Soon-Ok,Kim, Wan-Joo,Kim, Young-Myeong,Jung, Jong-Wha,An, Hongchan,Suh, Young-Ger
-
scheme or table
p. 4416 - 4420
(2010/04/05)
-
- Benzo[b]furane and benzo[b]thiophene derivatives
-
The present invention relates to benzo[b]furane and benzo[b]thiophene derivatives of the general formula IV as the free base or salts thereof and their use.
- -
-
Page/Page column 18
(2008/06/13)
-
- Aryl triazines as LPAAT-SS inhibitors and uses thereof
-
The invention relates to aryl triazines and uses thereof, including to inhibit lysophosphatidic acid acyltransferase β (LPAAT-β) activity and/or proliferation of cells such as tumor cells.
- -
-
-
- Pyrimidin derivatives
-
The invention relates to new pharmaceutically active compounds which are are P2-purinoceptor 7-transmembrane (TM) G-protein coupled receptor antagonists, compositions containing them and processes for their preparation.
- -
-
-