Synthesis and Structure-Activity Relationships of the Novel Antimalarials 5-Pyridinyl-4(1 H)-Pyridones
Malaria is still one of the most prevalent parasitic infections in the world, with half of the world's population at risk for malaria. The effectiveness of current antimalarial therapies, even that of the most recent class of antimalarial drugs (artemisin
Bueno, José M.,Calderon, Félix,Chicharro, Jesús,De La Rosa, Juan C.,Díaz, Beatriz,Fernández, Jorge,Fiandor, José M.,Fraile, María T.,García, Mercedes,Herreros, Esperanza,García-Pérez, Adolfo,Lorenzo, Milagros,Mallo, Araceli,Puente, Margarita,Saadeddin, Anas,Ferrer, Santiago,Angulo-Barturen, I?igo,Burrows, Jeremy N.,León, María L.
p. 3422 - 3435
(2018/05/01)
NOVEL HETEROCYCLIC COMPOUNDS
4-pyridone derivatives of Formula (I) and pharmaceutically acceptable derivatives thereof, processes for their preparation, pharmaceutical formulations thereof and their use in chemotherapy of certain parasitic infections such as malaria, are provided.
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Page/Page column 56
(2008/06/13)
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