91032-26-7 Usage
Uses
Used in Pharmaceutical Industry:
Ristomycin A aglycone, 34-O-2-(acetylamino)-2-deoxy-.beta.-D-glucopyranosyl-22,31-dichloro-7-demethyl-64-O-demethyl-19-deoxy-56-O-2-deoxy-2-(8-methyl-1-oxononyl)amino-.beta.-D-glucopyranosyl-42-O-.alpha.-D-mannopyranosylis used as a broad-spectrum antibiotic for the treatment of various bacterial infections, particularly those caused by Gram-positive bacteria, including antibiotic-resistant strains such as MRSA (Methicillin-resistant Staphylococcus aureus) and E. faecalis (Enterococcus faecalis). Its unique chemical structure and modifications contribute to its potent antimicrobial activity and potential to overcome antibiotic resistance.
Used in Research and Development:
Ristomycin A aglycone, 34-O-2-(acetylamino)-2-deoxy-.beta.-D-glucopyranosyl-22,31-dichloro-7-demethyl-64-O-demethyl-19-deoxy-56-O-2-deoxy-2-(8-methyl-1-oxononyl)amino-.beta.-D-glucopyranosyl-42-O-.alpha.-D-mannopyranosylis used as a valuable compound for studying the structure-activity relationship of glycopeptide antibiotics. Researchers can analyze the effect of various hydrophobic substituents and sugar moieties on the biological activity of these antibiotics, which can help in the design and synthesis of new and more effective antibiotic derivatives.
Used in Drug Development:
Ristomycin A aglycone, 34-O-2-(acetylamino)-2-deoxy-.beta.-D-glucopyranosyl-22,31-dichloro-7-demethyl-64-O-demethyl-19-deoxy-56-O-2-deoxy-2-(8-methyl-1-oxononyl)amino-.beta.-D-glucopyranosyl-42-O-.alpha.-D-mannopyranosylserves as a starting point for the development of new teicoplanin derivatives with improved properties and enhanced antimicrobial activity. These derivatives may help address the growing issue of antibiotic resistance and provide more effective treatment options for various bacterial infections.
Biological Activity
teicoplanin a2-2 is a new glycopeptide antibiotic belonging to the same family as vancomycin. teicoplanin consists of five major components (a2-1 through a2-5), one hydrolysis component (a3-1), and four minor components (rs-1 through rs-4) [1]. teicoplanin is isolated from the fermentation broth of actinoplanes teichomyceticus nov. sp. and has been endowed with outstanding bactericidal activity against grampositive pathogenic bacteria [2].[1] bernareggi a, borghi a, borgonovi m, et al. teicoplanin metabolism in humans[j]. antimicrobial agents and chemotherapy, 1992, 36(8): 1744-1749.[2] s. somma, l. gastaldo and a. corti. teicoplanin, a new antibiotic from actinoplanes teichomyceticus nov. sp. antimicrobial agents and chemotherapy 26(6), 917-923 (1984).[3] rowland m. clinical pharmacokinetics of teicoplanin[j]. clinical pharmacokinetics, 1990, 18(3): 184-209.
in vitro
teicoplanin inhibited cell wall synthesis in bacillus subtilis, the inhibition is accompanied by an intracellular accumulation of udp-n-acetyl-muramyl-pentapeptide. in a cell-free system from bacillus stearothermophilus, treatment with teicoplanin (40 μg/ml) inhibited 50% of peptidoglycan synthesis, and 100 μg/ml teicoplanin totally suppressed peptidoglycan synthesis [2].
in vivo
following intravenous administration, concentrations of teicoplanin were high in lung and bone tissue and low in fat in relative to those in plasma in patients with normal renal function. animal data showed high concentrations in most tissues, and particularly high in liver and kidneys [3].
Check Digit Verification of cas no
The CAS Registry Mumber 91032-26-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 9,1,0,3 and 2 respectively; the second part has 2 digits, 2 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 91032-26:
(7*9)+(6*1)+(5*0)+(4*3)+(3*2)+(2*2)+(1*6)=97
97 % 10 = 7
So 91032-26-7 is a valid CAS Registry Number.
InChI:InChI=1/C88H97Cl2N9O33/c1-33(2)8-6-4-5-7-9-60(108)94-68-74(113)71(110)58(31-101)129-87(68)132-78-55-25-40-26-56(78)126-52-17-13-38(23-47(52)90)77(131-86-67(92-34(3)103)73(112)70(109)57(30-100)128-86)69-84(121)98-66(85(122)123)45-28-42(105)29-54(127-88-76(115)75(114)72(111)59(32-102)130-88)61(45)44-22-37(12-14-49(44)106)63(81(118)99-69)96-83(120)65(40)97-82(119)64-39-20-41(104)27-43(21-39)124-53-24-36(11-15-50(53)107)62(91)80(117)93-48(79(116)95-64)19-35-10-16-51(125-55)46(89)18-35/h10-18,20-29,33,48,57-59,62-77,86-88,100-102,104-107,109-115H,4-9,19,30-32,91H2,1-3H3,(H,92,103)(H,93,117)(H,94,108)(H,95,116)(H,96,120)(H,97,119)(H,98,121)(H,99,118)(H,122,123)/t48-,57-,58-,59-,62+,63-,64+,65-,66-,67-,68-,69+,70-,71-,72-,73-,74-,75+,76+,77-,86+,87+,88+/m1/s1
