(Phenylpiperidinyl)cyclohexylsulfonamides: Development of α1a/1d-selective adrenergic receptor antagonists for the treatment of benign prostatic hyperplasia/lower urinary tract symptoms (BPH/LUTS)
Although α1 adrenergic receptor blockers can be very effective for the treatment of benign prostatic hyperplasia/lower urinary tract symptoms (BPH/LUTS), their usage is limited by CV-related side-effects that are caused by the subtype non-selec
Chiu, George,Li, Shengjian,Connolly, Peter J.,Pulito, Virginia,Liu, Jingchun,Middleton, Steven A.
p. 3930 - 3934
(2008/02/11)
Aminocyclohexylsulfonamides: Discovery of metabolically stable α1a/1d-selective adrenergic receptor antagonists for the treatment of benign prostatic hyperplasia/lower urinary tract symptoms (BPH/LUTS)
Benign prostatic hyperplasia/lower urinary tract symptoms (BPH/LUTS) can be effectively treated by α1 adrenergic receptor antagonists, but these drugs also produce side effects that are related to their subtype non-selective nature. To overcome
Chiu, George,Li, Shengjian,Cai, Hong,Connolly, Peter J.,Peng, Sean,Stauber, Kathe,Pulito, Virginia,Liu, Jingchun,Middleton, Steven A.
p. 6123 - 6128
(2008/03/14)
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