Synthesis, Protein Tyrosine Phosphatase 1B Inhibitory, and Anti-hyperglycemic Activities of Some “(E)-3-aryl-1-(2-pyrrolyl)-2-propenone” Derivatives
This study aims at design, as protein tyrosine phosphatase 1B (PTP1B) synthesis and biological evaluation of some heterocyclic derivatives of chalcone inhibitors. These derivatives were designed on the basis of prerequisite structural features required fo
Jain, Ankit,Jain, Dinesh K.
p. 517 - 525
(2022/01/26)
Synthesis and biological evaluation of pyrrole-based chalcones as CYP1 enzyme inhibitors, for possible prevention of cancer and overcoming cisplatin resistance
Inhibitors of CYP1 enzymes may play vital roles in the prevention of cancer and overcoming chemo-resistance to anticancer drugs. In this letter, we report synthesis of twenty-three pyrrole based heterocyclic chalcones which were screened for inhibition of
Synthesis and biologic activities of some novel heterocyclic chalcone derivatives
We synthesized 36 chalcone-like (E)-3-(substitutedphenyl)-1-hetrylprop-2- en-1-ones by condensing 2-acetylfuran/2-acetylpyrrole with substituted benzaldehydes under basic conditions. Of the 36 molecules synthesized, 10 are new to the literature. Bio-evalu