Vitamin K Dependent Carboxylation: Synthesis and Biological Properties of Tetrazolyl Analogues of Pentapeptidic Substrates
The pentapeptides Phe-Leu-X-Glu-Val and Phe-Leu-X-X-Val, where X= 4-(5H-tetrazolyl)-2-aminobutyric acid (tetrazolyl analogue of glutamic acid), were synthesized by addition of tri-n-butyltin azide to the corresponding nitrile-containing peptides.These tet