- Synthesis method of omeprazole intermediate
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The invention relates to a synthesis method of an omeprazole intermediate, in particular to a synthesis method of an omeprazole intermediate. According to the technical scheme, the synthesis method ischaracterized in that 3, 5-dimethyl-4-nitropyridine-N-oxide is used as an initial raw material, and 2-chloromethyl-3, 5-dimethyl-4-methoxypyridine is obtained through a methoxylation reaction, a methylation reaction, a rearrangement reaction and a chlorination reaction. The synthesis method of the omeprazole intermediate is high in yield, and the yield can reach 78.9%.
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Paragraph 0021; 0024-0029
(2020/07/13)
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- Certain pyridyl-N-oxide intermediates for the preparation of omeprazole
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Novel compounds of the formula STR1 wherein R is H or CH3, a process for their preparation, and their use as intermediates in the preparation of pharmaceutically useful compounds, e.g. substituted benzimidazoles containing a pyridine radical, i.a. omeprazole.
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