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6,6-Dimethyl-6,7-dihydro-1H-indazol-4(5H)-one, also known as 6,6-dimethylindoline-2,3-dione, is a heterocyclic chemical compound with the molecular formula C10H11NO. It is used as a building block in the synthesis of various pharmaceuticals and organic compounds, particularly in the development of central nervous system (CNS) drugs.

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  • 912259-11-1 Structure
  • Basic information

    1. Product Name: 6,6-dimethyl-6,7-dihydro-1H-indazol-4(5H)-one
    2. Synonyms: 6,6-dimethyl-6,7-dihydro-1H-indazol-4(5H)-one;6,6-Dimethyl-1,5,6,7-tetrahydro-indazol-4-one
    3. CAS NO:912259-11-1
    4. Molecular Formula: C9H12N2O
    5. Molecular Weight: 164.20438
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 912259-11-1.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: 6,6-dimethyl-6,7-dihydro-1H-indazol-4(5H)-one(CAS DataBase Reference)
    10. NIST Chemistry Reference: 6,6-dimethyl-6,7-dihydro-1H-indazol-4(5H)-one(912259-11-1)
    11. EPA Substance Registry System: 6,6-dimethyl-6,7-dihydro-1H-indazol-4(5H)-one(912259-11-1)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 912259-11-1(Hazardous Substances Data)

912259-11-1 Usage

Uses

Used in Pharmaceutical Industry:
6,6-Dimethyl-6,7-dihydro-1H-indazol-4(5H)-one is used as an intermediate in the synthesis of various pharmaceuticals and organic compounds. Its unique structure and properties make it an important building block in drug discovery, particularly for the development of CNS drugs.
Used in Drug Discovery:
6,6-Dimethyl-6,7-dihydro-1H-indazol-4(5H)-one is used as a potential building block in drug discovery, with potential applications in the treatment of various diseases and medical conditions. Its unique structure and properties make it a valuable compound for the development of new therapeutic agents.

Check Digit Verification of cas no

The CAS Registry Mumber 912259-11-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 9,1,2,2,5 and 9 respectively; the second part has 2 digits, 1 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 912259-11:
(8*9)+(7*1)+(6*2)+(5*2)+(4*5)+(3*9)+(2*1)+(1*1)=151
151 % 10 = 1
So 912259-11-1 is a valid CAS Registry Number.

912259-11-1SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name 4H-Indazol-4-one, 2,5,6,7-tetrahydro-6,6-dimethyl-

1.2 Other means of identification

Product number -
Other names 6,6-Dimethyl-6,7-dihydro-1H-indazol-4(5H)-one

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:912259-11-1 SDS

912259-11-1Relevant articles and documents

Novel crown ether functionalized imidazolium-based acidic ionic liquid catalyzed synthesis of pyrazole derivatives under solvent-free conditions

Patil, Dayanand,Chandam, Dattatraya,Mulik, Abhijeet,Jagdale, Suryabala,Patil, Prasad,Deshmukh, Madhukar

, p. 6843 - 6858 (2015/08/18)

Abstract An innovatively designed novel crown ether functionalized imidazolium-based reusable acidic ionic liquid [crown ether MIm] [HSO4] has been efficiently implemented for the synthesis of pyrazole derivatives using various substituted enaminones, hydrazine hydrate and phenyl hydrazine under solvent-free conditions. Structural novelty and task efficiency of the catalyst, high yields of desired products, greener approach attributing high atom economy and solvent-free conditions render this protocol suitable to cope with the current demand in contemporary organic chemistry. The inventive idea of utilizing crown ether functionalized ionic liquid as a catalyst was for the first time demonstrated in this protocol.

TRICYCLIC COMPOUNDS AS ALLOSTERIC MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS

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Page/Page column 21, (2012/02/02)

The present invention describes and claims compounds of the Structural Formula (I), Structural Formula (II), or Structural Formula (III). In Formula (I), R1, R2, R3 and R3' are -H or methyl, or R3 and R3' taken together form a double bond, or R3' is -H and R2 and R3 taken together form a spiro-cyclopropyl substituent, R4 is -H or -F, and R5 is -H, methyl, -Cl or -Br. In Formula (II), R1 is -H, ethyl-, isopropyl-, cyclopropyl-, methyl- or methoxy-, R4 is -H or -F, and "Y" is: (a) -CH2-; (b) -CR6H-O-CR7R8-, wherein R6, R7, and R8 are independently -H or methyl; (c) -CR6H-N(R9)-CR7R8-, wherein R6, R7, and R8 are independently -H or methyl; (d) -CH2-C(R9)(R10)-C(R7)(R8)-, wherein R7, R8, R9 and R10 are independently -H or -methyl, or both R7 and R8 are -F, R9 and R10 are independently -H or -methyl, or both R9 and R10 are -F, or R9 and R10 taken together are (O=), which together with the carbon to which they are attached forms a carbonyl group.

TRICYCLIC COMPOUNDS AS ALLOSTERIC MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS

-

Page/Page column 21, (2012/02/02)

The present invention describes and claims compounds of the Structural Formula I, Structural Formula II, or Structural Formula III: wherein R1, R2, R3 and R3' are -H or methyl, or R3 and R3 taken together form a double bond, or R3' is -H and R2 and R3 taken together form a spiro-cyclopropyl substituent, R4 is -H or -F, and R5 is -H, methyl, -CI or -Br, Formula II wherein R1 is -H, ethyl-, isopropyl-, cyclopropyl-, methyl- or methoxy-, R4 is -H or -F, and "Y" is: (a) -CH2-; (b) -CR6H-0-CR7R8-, wherein R6, R7, and R8 are independently - H or methyl; (c) -CR6H-N(R9)-CR7R8-, wherein R6, R7, and R8 are independently -H or methyl; (d) -CH2-C(R9)(R10)-C(R7)(R8)-, wherein R7, R8, R9 and R10 are independently - H or -methyl, or both R7 and R8 are -F, R9 and R10 are independently -H or -methyl, or both R9 and R10 are -F, or R9 and R10 taken together are (0=), which together with the carbon to which they are attached forms a carbonyl group.

HETEROTRICYCLIC COMPOUNDS AS POSITIVE ALLOSTERIC MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS

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Page/Page column 26-27, (2010/08/04)

The present invention relates to novel compounds of Formula (I), wherein wherein X1, X2, Y, Z1, Z2, Z3, M and (A)m are defined as in Formula (I); invention compounds are modulators of metab

Synthesis and structural study of tetrahydroindazolones

Claramunt, Rosa M.,López, Concepción,Pérez-Medina, Carlos,Pinilla, Elena,Torres, M. Rosario,Elguero, José

, p. 11704 - 11713 (2007/10/03)

Multinuclear magnetic resonance spectroscopy allowed us to characterize four 1(2),5,6,7-tetrahydro-4H-indazol-4-one derivatives (1-4) and establish the most stable tautomer in each case. The crystal structure of 6,6-dimethyl-1(2),5,6,7-tetrahydro-4H-indaz

Benzodipyrazoles: A new class of potent CDK2 inhibitors

D'Alessio, Roberto,Bargiotti, Alberto,Metz, Suzanne,Brasca, M. Gabriella,Cameron, Alexander,Ermoli, Antonella,Marsiglio, Aurelio,Polucci, Paolo,Roletto, Fulvia,Tibolla, Marcellino,Vazquez, Michael L.,Vulpetti, Anna,Pevarello, Paolo

, p. 1315 - 1319 (2007/10/03)

The synthesis and the preliminary expansion of this new class of CDK2 inhibitors are presented. The synthesis was accomplished using a solution-phase protocol amenable to rapid parallel expansion and suitable to be scaled-up in view of possible lead devel

A Novel Amino Protection-Deprotection Procedure and Its Application in Solid Phase Peptide Synthesis

Bycroft, Barrie W.,Chan, Weng C.,Chhabra, Siri Ram,Teesdale-Spittle, Paul H.,Hardy, Paul M.

, p. 776 - 777 (2007/10/02)

N-4,4-Dimethyl-2,6-dioxocyclohexylidenemethyl (Dcm) amino acids are readily prepared and the protecting group can be removed with hydrazine at room temperature; their potential in solid phase peptide synthesis is illustrated.

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