- Regioselective synthesis of 2-amino-substituted 1,3,4-oxadiazole and 1,3,4-thiadiazole derivatives via reagent-based cyclization of thiosemicarbazide intermediate
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A regioselective, reagent-based method for the cyclization reaction of 2-amino-1,3,4-oxadiazole and 2-amino-1,3,4-thiadiazole core skeletons is described. The thiosemicarbazide intermediate 3 was reacted with EDC·HCl in DMSO or p-TsCl, triethylamine in N-
- Yang, Seung-Ju,Lee, Seok-Hyeong,Kwak, Hyun-Jung,Gong, Young-Dae
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p. 438 - 444
(2013/04/10)
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- The reactions of cyclization of thiosemicarbazide derivatives to 1,2,4-triazole or 1,3,4-thiadiazole system
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In the reaction of hydrazide of formic, nicotinic and benzoic acid with isothiocyanates were obtained the respective thiosemicarbazide derivatives [I-XII]. Further cyclization with 2% NaOH solution led to formation of derivatives Δ2-1,2,4-triaz
- Dobosz, Maria,Pitucha, Monika,Wujec, Monika
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- Mesoionic xanthine analogues: Antagonists of adenosine receptors
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A variety of mesoionic xanthines including mesoionic thiazolo[3,2-α]pyrimidines, benzothiazolopyrimidines, and 1,3,4-thiadiazolo[3,2-α]pyrimidines were antagonists of A1-adenosine receptors (inhibition of binding of [3H]-cyclohexylad
- Glennon,Tejani-Butt,Padgett,Daly
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p. 1364 - 1367
(2007/10/02)
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