912763-45-2

Basic information

• Product Name: 1H-Imidazole, 5-(3-chlorophenyl)-
• Synonyms: 1H-Imidazole, 5-(3-chlorophenyl)-
• CAS NO: 912763-45-2
• Molecular Formula: C₉H₇ClN₂
• Molecular Weight: 178.62
• Mol File: 912763-45-2.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1H-Imidazole, 5-(3-chlorophenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Imidazole, 5-(3-chlorophenyl)-(912763-45-2)
• EPA Substance Registry System: 1H-Imidazole, 5-(3-chlorophenyl)-(912763-45-2)

Safety Data

• Hazardous Substances Data: 912763-45-2(Hazardous Substances Data)

Usage

Derivative of imidazole

A modified version of the imidazole molecule an aromatic heterocyclic compound with a five-membered ring.

Contains a chlorophenyl group

A phenyl ring (a six-membered ring with alternating single and double carbon-carbon bonds) with a chlorine atom attached.

Industrial and pharmaceutical applications

Utilized in various industries, such as pharmaceuticals and agriculture, for the production of drugs and chemicals.

Building block for synthesis

Serves as a fundamental component in the creation of other pharmaceutical drugs and agricultural chemicals.

Potential biological activities

Possesses possible antimicrobial, antifungal, and anti-inflammatory properties, which have been the subject of scientific research.

Research and development

May be used in the investigation and creation of new chemical and pharmaceutical products, highlighting its versatility in the field.

Wide range of applications

Due to its unique structure and properties, 1H-Imidazole, 5-(3-chlorophenyl)has the potential to be employed in numerous applications across different industries.

Upstream product

• 41011-01-2 2-bromo-1-(3-chloro-phenyl)-ethanone 
• 77287-34-4 formamide 

Relevant articles and documents

Azole-Based Indoleamine 2,3-Dioxygenase 1 (IDO1) Inhibitors

The heme enzyme indoleamine 2,3-dioxygenase 1 (IDO1) plays an essential role in immunity, neuronal function, and aging through catalysis of the rate-limiting step in the kynurenine pathway of tryptophan metabolism. Many IDO1 inhibitors with different chemotypes have been developed, mainly targeted for use in anti-cancer immunotherapy. Lead optimization of direct heme iron-binding inhibitors has proven difficult due to the remarkable selectivity and sensitivity of the heme-ligand interactions. Here, we present experimental data for a set of closely related small azole compounds with more than 4 orders of magnitude differences in their inhibitory activities, ranging from millimolar to nanomolar levels. We investigate and rationalize their activities based on structural data, molecular dynamics simulations, and density functional theory calculations. Our results not only expand the presently known four confirmed chemotypes of sub-micromolar heme binding IDO1 inhibitors by two additional scaffolds but also provide a model to predict the activities of novel scaffolds.

Cyclometallated tetradentate Pt (II) complexes comprised of one or two imidazole rings with a twisted aryl group bonded to N-1

Novel cyclometallated tetradentate Pt(II) compounds are provided. The compounds comprise two ligands that contain a 5-membered carbocyclic or heterocyclic ring, one of which contains an imidazole ring with a twisted aryl group attached to N-1 and a second

Structure-activity relationships of 2,4-diphenyl-1H-imidazole analogs as CB2 receptor agonists for the treatment of chronic pain

A series of 2,4-diphenyl-1H-imidazole analogs have been synthesized and displayed potent human CB2 agonist activity. Many of these analogs showed high functional selectivity over human CB1 receptors. The syntheses, structure-activity relationships, and selected pharmacokinetic data of these analogs are described.