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91296-86-5

Difluoxacin hydrochloride, also known as Diflomox, is a fluoroquinolone antibiotic that exhibits potent activity against a wide range of aerobic and anaerobic bacteria. It functions as a DNA gyrase inhibitor, interfering with bacterial DNA replication, transcription, and repair processes, thereby exerting its bactericidal effects.
Used in Pharmaceutical Industry:
Difluoxacin hydrochloride is used as an antibacterial agent for treating various bacterial infections, including respiratory, urinary, and skin infections. Its broad-spectrum activity and ability to penetrate various tissues make it a versatile treatment option for a range of bacterial pathogens.
Used in Research and Development:
Difluoxacin hydrochloride is used as a DNA gyrase inhibitor in research settings to study the mechanisms of bacterial resistance and the development of new antibiotics. Its structural similarity to other fluoroquinolones, such as norfloxacin, allows for comparative studies and the exploration of structure-activity relationships in drug design.

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  • 91296-86-5 Structure

  • Basic information

    1. Product Name: Difluoxacin hydrochloride
    2. Synonyms: VETRANAL;6-FLUORO-1-(4-FLUOROPHENYL)-1,4-DIHYDRO-7-(4-METHYLPIPERAZINO)-4-OXO-3-QUINOLINECARBOXYLIC ACID HYDROCHLORIDE;DIFLUOXACIN HYDROCHLORIDE;DIFLOXACIN HCL;DIFLOXACIN HYDROCHLORIDE;Difluoxacin HCL;3-Quinolinecarboxylic acid, 6-fluoro-1-(4-fluorophenyl)-1,4-dihydro-7-(4-methyl-1-piperazinyl)-4-oxo-, monohydrochloride;6-Fluoro-1-(4-fluorophenyl)-7-(4-methylpiperazin-1-yl)-4-oxoquinoline-3-carboxylic acid hydrochloride
    3. CAS NO:91296-86-5
    4. Molecular Formula: C21H19F2N3O3*ClH
    5. Molecular Weight: 435.85
    6. EINECS: 1806241-263-5
    7. Product Categories: Active Pharmaceutical Ingredients;Chiral Reagents;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals;DICURAL
    8. Mol File: 91296-86-5.mol

  • Chemical Properties

    1. Melting Point: >245°C (dec.)
    2. Boiling Point: 595.5 °C at 760 mmHg
    3. Flash Point: 313.9 °C
    4. Appearance: off-white to pale yellow solid
    5. Density: 1.409 g/cm3
    6. Vapor Pressure: 5.01E-15mmHg at 25°C
    7. Refractive Index: 1.629
    8. Storage Temp.: 0-6°C
    9. Solubility: Soluble in aqueous buffer
    10. CAS DataBase Reference: Difluoxacin hydrochloride(CAS DataBase Reference)
    11. NIST Chemistry Reference: Difluoxacin hydrochloride(91296-86-5)
    12. EPA Substance Registry System: Difluoxacin hydrochloride(91296-86-5)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany: 3
    5. RTECS: VB2008975
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 91296-86-5(Hazardous Substances Data)

91296-86-5 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 91296-86-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 9,1,2,9 and 6 respectively; the second part has 2 digits, 8 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 91296-86:
(7*9)+(6*1)+(5*2)+(4*9)+(3*6)+(2*8)+(1*6)=155
155 % 10 = 5
So 91296-86-5 is a valid CAS Registry Number.
InChI:InChI=1/C21H19F2N3O3/c1-24-6-8-25(9-7-24)19-11-18-15(10-17(19)23)20(27)16(21(28)29)12-26(18)14-4-2-13(22)3-5-14/h2-5,10-12H,6-9H2,1H3,(H,28,29)

91296-86-5 Well-known Company Product Price

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  • Sigma-Aldrich

  • (Y0001423)  Difloxacinhydrochloride  

  • 91296-86-5

  • Y0001423

  • 1,880.19CNY

  • Detail

91296-86-5SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 16, 2017

Revision Date: Aug 16, 2017

1.Identification

1.1 GHS Product identifier

Product name Difloxacin Hydrochloride Salt

1.2 Other means of identification

Product number -
Other names 6-fluoro-1-(4-fluorophenyl)-7-(4-methylpiperazin-1-yl)-4-oxoquinoline-3-carboxylic acid,hydrochloride

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:91296-86-5 SDS

91296-86-5Upstream product

91296-86-5Downstream Products

91296-86-5Relevant articles and documents

Preparation method of quinolone carboxylic acid derivative or phthalazinone carboxylic acid derivative

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Paragraph 0089-0091; 0179, (2021/10/27)

The invention belongs to the field of pharmaceutical chemicals, relates to a preparation method of a quinolone carboxylic acid derivative or a phthalazinone carboxylic acid derivative, and particularly relates to a preparation method of a 7-substituted-3-quinolone carboxylic acid derivative or a 7-substituted-1,5-phthalazinone carboxylic acid derivative. The preparation method comprises the following steps: (1) in an organic solvent, carrying out coupling reaction on a boron chelate II and organic amine III in the presence of an organosilicon compound to obtain a compound IV; and (2) mixing the compound IV with hydrochloric acid, and then filtering and separating the precipitated compound I. Compared with conventional methods, the preparation method provided by the invention has the advantages that the conditions are milder, the hydrolysis of the substrate quinoline carboxylic acid boric acid ester can be reduced, and meanwhile, the influence of a byproduct HF on the product purity is avoided. The method is high in yield and high in purity; compared with the traditional alkali, the organic silicon is more suitable for industrial preparation of the 7-substituted-3-quinolone carboxylic acid derivative or the 7-substituted-1,5-phthalazinone carboxylic acid derivative.

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