91322-00-8

Basic information

• Product Name: 5-Amino-2,4,6-trichloropyrimidine
• Synonyms: 5-Amino-2,4,6-trichloropyrimidine;2,4,6-Trichloro-5-pyrimidinamine;2,4,6-Trichloro-pyrimidin-5-ylamine;2,4,6-TRICHLOROPYRIMIDIN-5-AMINE(WXC08712)
• CAS NO: 91322-00-8
• Molecular Formula: C₄H₂Cl₃N₃
• Molecular Weight: 198.43778
• Mol File: 91322-00-8.mol

Chemical Properties

• Boiling Point: 260℃
• Flash Point: 111℃
• Appearance: /
• Density: 1.740
• Vapor Pressure: 0.013mmHg at 25°C
• Refractive Index: 1.645
• PKA: -3.97±0.10(Predicted)
• CAS DataBase Reference: 5-Amino-2,4,6-trichloropyrimidine(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Amino-2,4,6-trichloropyrimidine(91322-00-8)
• EPA Substance Registry System: 5-Amino-2,4,6-trichloropyrimidine(91322-00-8)

Safety Data

• Hazardous Substances Data: 91322-00-8(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Synthesis:
5-Amino-2,4,6-trichloropyrimidine is used as a key intermediate in the synthesis of various pharmaceuticals. Its unique structure allows for the development of new drugs with potential therapeutic applications in medicine.
Used in Agrochemical Production:
In the agrochemical industry, 5-Amino-2,4,6-trichloropyrimidine serves as a building block for the creation of effective pesticides and other crop protection agents. Its incorporation into these products enhances their pesticidal properties, contributing to improved agricultural yields.
Used in Organic Compounds Production:
5-Amino-2,4,6-trichloropyrimidine is utilized as a versatile starting material in the production of a wide range of organic compounds. Its reactivity and functional groups enable the synthesis of various organic molecules with diverse applications in different industries.
Used in Material Science:
In the field of material science, 5-Amino-2,4,6-trichloropyrimidine has potential applications in the development of new materials with unique properties. Its incorporation into these materials can lead to advancements in areas such as polymer science, nanotechnology, and other emerging fields.
Overall, 5-Amino-2,4,6-trichloropyrimidine is a multifaceted chemical compound with a broad range of applications across various industries, including pharmaceuticals, agrochemicals, organic compounds production, and material science. Its unique structure and reactivity make it an essential intermediate in chemical synthesis and a promising candidate for the development of innovative products and technologies.

InChI:InChI=1/C4H2Cl3N3/c5-2-1(8)3(6)10-4(7)9-2/h8H2

Upstream product

• 4359-87-9 2,4,6-trichloro-5-nitropyrimidine 

Downstream Products

• 55583-59-0 2,5-diamino-4,6-dichloropyrimidine 
• 116856-56-5 3-(4-{2-[6-Amino-9-((1R,2S,3R,4S)-4-ethylcarbamoyl-2,3-dihydroxy-cyclopentyl)-9H-purin-2-ylamino]-ethyl}-phenyl)-propionic acid tert-butyl ester 

Relevant articles and documents

Synthesis of ticagrelor analogues belonging to 1,2,3-triazolo[4,5-d]pyrimidines and study of their antiplatelet and antibacterial activity

Based on the recent observation that the antiplatelet agent ticagrelor and one of its metabolite exert bactericidal activity against gram-positive bacteria, a series of 1,2,3-triazolo[4,5-d]pyrimidines structurally related to ticagrelor were synthesized and examined as putative antiplatelet and antibacterial agents. The aim was to assess the possibility of dissociating the two biological properties and to find novel 1,2,3-triazolo[4,5-d]pyrimidines expressing antiplatelet activity and devoid of in vitro antibacterial activity. The new compounds synthesized were known metabolites of ticagrelor as well as structurally simplified analogues. Some of them were found to express antiplatelet activity and to lose the antibacterial activity, supporting the view that the two activities were not necessarily linked.

FERROPORTIN INHIBITORS AND METHODS OF USE

The subject matter described herein is directed to Ferroportin inhibitor compounds of Formula I and pharmaceutical salts thereof, methods of preparing the compounds, pharmaceutical compositions comprising the compounds and methods of administering the compounds for prophylaxis and/or treatment of diseases caused by a lack of hepcidin or iron metabolism disorders, particularly iron overload states, such as thalassemia, sickle cell disease and hemochromatosis.

HEXAHYDROOXAZINOPTERINE COMPOUNDS

The present invention provides mTOR inhibitors of the formula wherein the variables are as defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds; methods of making the compounds and intermediates thereof; and methods of using the compounds.