- Synthetic method of bimatoprost
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The invention relates to a synthetic method of bimatoprost, and belongs to the technical field of chemical synthesis. According to the method, doxazosin is synthesized by adopting the following synthesis route different from the conventional technology, s
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Paragraph 0053-0058; 0099-0102
(2020/05/01)
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- Synthesis method of carboprost and tretrel carprost
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The invention relates to a synthesis method of carboprost and tretrel carprost. According to the synthesis method of the carboprost, Corey lactone which is low in price and easy to obtain serves as the initial raw matrial, the carboprost is synthesized through the seven-step reaction, operation is convenient, intermediates are stable, environmental protection and economical performance are realized, and reaction is easy to control. Compared with the prior art, the synthesis method has the advantages that when the intermediates are synthesized, no isomers can be generated, products are easy toseparate, the yield of the end product (carboprost) is high, the novel more effective method is provided for the artificial synthesis of the carboprost, and the method can also be used for simple andhigh-yield synthesis of related carboprost derivatives such as tretrel carprost.
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Paragraph 0050-0053; 0070-0073
(2019/10/01)
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- Eicosapentaenoic-acid-derived isoprostanes: Synthesis and discovery of two major isoprostanes
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The stereospecific synthesis of two all-syn-EPA-derived isoprostanes (iPs), 5-epi-8,12-iso-iPF3α-VI 17 and 8,12-iso-iPF3α-VI 18, has been accomplished. These two synthetic probes have been used to discover and identify their presence in human urine. The eventual quantitative measurement of these two iPs may be a valuable index of oxidative stress in people with eicosapentaenoic acid- (EPA) and docosahexaenoic acid- (DHA) enriched phospholipids.
- Chang, Chih-Tsung,Patel, Pranav,Kang, Namin,Lawson, John A.,Song, Wen-Liang,Powell, William S.,FitzGerald, Garret A.,Rokach, Joshua
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scheme or table
p. 5523 - 5527
(2009/05/30)
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