Facile allylation of N-Boc and N-Cbz imines with allyltrichlorosilane promoted by DMF
Facile allylation of various N-Boc and N-Cbz imines with allyltrichlorosilane has been effected using N,N-dimethylformamide (DMF) as the activator. The N-Boc and N-Cbz homoallylic amines were obtained in good to high yields under mild conditions. Copyrigh
Wu, Pengcheng,Sun, Jian
p. 1003 - 1010
(2008/09/18)
RCM-mediated synthesis of trifluoromethyl-containing nitrogen heterocycles
(Chemical Equation Presented) A ring-closing metathesis mediated pathway to trifluoromethyl-containing piperidines is detailed. This involves the development of a synthetic route to a new (trifluoromethyl)allylating reagent via a Diels-Alder/retro-Diels-Alder strategy, its application in the synthesis of a series of trifluormethyl-substituted diolefin recursors for ring-closing metathesis, and eventually the successful cyclization of these precursor molecules into the corresponding functionalized piperidines.
De Matteis, Valeria,Van Delft, Floris L.,Jakobi, Harald,Lindell, Stephen,Tiebes, Joerg,Rutjes, Floris P. J. T.
p. 7527 - 7532
(2007/10/03)
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