Synthesis of 4-(Fmoc-aminoacyloxymethyl)phenoxyacetic acids for use in solid-phase peptide synthesis
The synthesis of 4-(Fmoc-aminoacyloxymethyl)phenoxyacetic acids was achieved in high yield by the reaction of Fmoc-amino acids with (4-iodomethylphenoxy)acetic acid 2-oxo-2-phenylethyl ester. The removal of the temporary protecting group, phenacyl ester,