- Ti(III)-MEDIATED REDUCTIONS OF N-HYDROXY IMIDAZOLES TO 1-PROTIO-2,4(5)-DISUBSTITUTED DERIVATIVES
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N-Hydroxy imidazoles are converted via TiCl3 in MeOH/H2O to N-protio derivatives, useful precursors of chiral amino acids.
- Lipshutz, Bruce H.,Morey, Matthew C.
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- Preparation of imidazoles
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The present invention relates to preparation of imidazoles which are useful as pharmaceutical and agricultural chemicals. Specifically, the present invention relates to a process for preparing imidazoles of the formula (I): STR1 which comprises conducting condensation among an α,α-dihaloaldehyde compound of the formula (II): STR2 an aldehyde compound of the formula: R2 --CHO and aqueous ammonia.
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- A One Step Synthesis of 4-Substituted Imidazoles. An Important Observation When N-Alkylating Imidazoles
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Imidazoles substituted in the 2-position with methyl, 1e, phenyl, 1a, 2-imidazole, 1b-d, or t-butyldiphenylsilyl, 1f, react with soft electrophiles 2 to give modest yields of 4(5)-C-alkylated-imidazoles 3 and N-alkylated products 5.These two products are readily separated by flash chromatography.
- Whitten, Jeffrey P.,Matthews, Donald P.,McCarthy, James R.,Barbuch, Robert J.
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p. 1845 - 1847
(2007/10/02)
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