Chemical synthesis of picornaviral protein primers of RNA replication
Naturally occurring nucleopeptidic replication primers (VPg-pUpU) of poliovirus and coxsackie virus were chemically synthesized. The synthesis was accomplished via block-coupling of two minimally protected fragments of the target structures: a short RNA-nucleopeptide and a longer peptide segment containing diverse side-chain functionalities. The synthetic VPg-pUpU of coxsackie virus was characterized by NMR spectroscopy. The Royal Society of Chemistry 2006.
Kriek, Nicole M. A. J.,Meeuwenoord, Nico J.,Van Den Elst, Hans,Heus, Hans A.,Van Der Marel, Gijsbert A.,Filippov, Dmitri V.
p. 3576 - 3586
(2008/10/09)
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