Modulation of Wnt signaling through inhibition of secreted frizzled-related protein I (sFRP-1) with N-substituted piperidinyl diphenylsulfonyl sulfonamides: Part II
Piperidinyl diphenylsulfonyl sulfonamides are a novel class of molecules that have inhibitory binding affinity for sFRP-1. As a secreted protein sFRP-1 inhibits the function of the secreted Wnt glycoprotein. Therefore, as inhibitors of sFRP-1 these small molecules facilitate the Wnt/β-catenin canonical signaling pathway. Details of the structure-activity relationships and biological activity of this structural class of compounds will be discussed.
Moore, William J.,Kern, Jeffrey C.,Bhat, Ramesh,Bodine, Peter V.N.,Fukyama, Shoichi,Krishnamurthy, Girija,Magolda, Ronald L.,Pitts, Keith,Stauffer, Barb,Trybulski, Eugene J.
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p. 190 - 201
(2010/04/06)
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