Novel self-immolative dendritic compounds which have a plurality of cleavable trigger units and hence can release a chemical moiety at their focal point upon a multi-triggering mechanism are disclosed. The novel self-immolative dendritic compounds are gated by a molecular logic gate, being either an AND or OR logic gate and hence can be beneficially used in a variety of biological, chemical and physical applications. Processes of preparing, compositions containing and methods utilizing the novel dendritic compounds are further disclosed.
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Page/Page column 25; sheet 5
(2010/11/24)
Prodrug activation gated by a molecular "OR" logic trigger
(Chemical Equation Presented) Molecules that define logic: A molecular "OR" logic gate trigger has been demon-strated by masking a functional group in a doxorubicin prodrug with a linker that contains two cleavable substrates (input). The prodrug molecule was activated by two different enzymes to release the parent drug (see scheme; input red; output (drug) blue).
Amir, Roey J.,Popkov, Mikhail,Lerner, Richard A.,Barbas III, Carlos F.,Shabat, Doron
p. 4378 - 4381
(2007/10/03)
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