- 4α-Bromo-5α-cholestan-3β-ol and nor-5α-cholestan- 3β-ol derivatives - Stereoselective synthesis and hormonal activity in Caenorhabditis elegans
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We describe the stereoselective synthesis of 4α-bromo-5α- cholestan-3β-ol, 21-nor-5α-cholestan-3β-ol, 27-nor-5α- cholestan-3β-ol and 21,27-bisnor-5α-cholestan-3β-ol. In order to clarify the in vivo metabolism of cholesterol, these compounds have been used
- Martin, Rene,Saini, Ratni,Bauer, Ingmar,Gruner, Margit,Kataeva, Olga,Zagoriy, Vyacheslav,Entchev, Eugeni V.,Kurzchalia, Teymuras V.,Knoelker, Hans-Joachim
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experimental part
p. 2303 - 2309
(2009/09/26)
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- 2-Methylene-1Alpha,25-Dihydroxy-18,19,21-Trinorvitamin D3 and Uses Thereof
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Compounds of formula I are provided where X1, X2 and X3 are independently selected from H or hydroxy protecting groups. Such compounds are used in preparing pharmaceutical compositions and are useful in treating a variety of biologic
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Page/Page column 9; 13
(2008/06/13)
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- 2-Methylene-1Alpha-Hydroxy-19,21-Dinorvitamin D3 Analogs and Uses Thereof
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Compounds of formula I are provided where X1 and X2 are independently selected from H or hydroxy protecting groups. Such compounds are used in preparing pharmaceutical compositions and are useful in treating a variety of biological c
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Page/Page column 11
(2008/06/13)
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- 2-Methylene-1alpha-Hydroxy-18,19,21-Trinorvitamin D3 Analogs and Uses Thereof
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Compounds of formula I are provided where X1 and X2 are independently selected from H or hydroxy protecting groups. Such compounds are used in preparing pharmaceutical compositions and are useful in treating a variety of biological c
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Page/Page column 12
(2008/06/13)
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- 2-Methylene-1Alpha,25-Dihydroxy-19,21-Dinorvitamin D3 Analogs and Uses Thereof
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Compounds of formula I are provided where X1, X2 and X3 are independently selected from H or hydroxy protecting groups. Such compounds are used in preparing pharmaceutical compositions and are useful in treating a variety
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Page/Page column 9; 12
(2008/06/13)
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- Synthesis and pharmacology of the isomeric methylheptyl-Δ8-tetrahydrocannabinols
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The synthesis of the 3-heptyl, and the eleven isomeric 3-methylheptyl-Δ8-tetrahydrocannabinols (3-7, R and S methyl epimers, and 8) has been carried out. The synthetic approach entailed the synthesis of substituted resorcinols, which were subjected to acid catalyzed condensation with trans-para-menthadienol to provide the Δ8-THC analogue. The 1'-, 2'- and 3'-methylheptyl analogues (3-5) are considerably more potent than Δ8-THC. The 4'-, 5'- and 6'-methylheptyl isomers (6-8) are approximately equal in potency to Δ8-THC. Copyright (C) 1998 Elsevier Science Ltd.
- Huffman, John W.,Liddle, John,Duncan Jr., Sammy G.,Yu, Shu,Martin, Billy R.,Wiley, Jenny L.
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p. 2383 - 2396
(2007/10/03)
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