917096-37-8

Basic information

• Product Name: (Z)-5-Methoxy-1-[4-(triflurormethyl)phenyl]-1-pentanone O-(2-Aminoethyl)oxime Maleate
• Synonyms: (Z) Fluvoxamine Maleate;(Z)-5-Methoxy-1-[4-(triflurormethyl)phenyl]-1-pentanone O-(2-Aminoethyl)oxime Maleate;(Z)-Fluvoxamine;(Z)-5-Methoxy-1-[4-(triflurorMethyl)phenyl]-1-pentanone O-(2-AMinoethyl)oxiMe;EP IMpurity B
• CAS NO: 917096-37-8
• Molecular Formula: C15H21F3N2O2
• Molecular Weight: 318.3346496
• Product Categories: Amines;Aromatics;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 917096-37-8.mol

Chemical Properties

• Melting Point: NA
• Appearance: /
• Storage Temp.: -20°C Freezer
• Solubility: DMSO (Slightly), Methanol (Slightly)
• CAS DataBase Reference: (Z)-5-Methoxy-1-[4-(triflurormethyl)phenyl]-1-pentanone O-(2-Aminoethyl)oxime Maleate(CAS DataBase Reference)
• NIST Chemistry Reference: (Z)-5-Methoxy-1-[4-(triflurormethyl)phenyl]-1-pentanone O-(2-Aminoethyl)oxime Maleate(917096-37-8)
• EPA Substance Registry System: (Z)-5-Methoxy-1-[4-(triflurormethyl)phenyl]-1-pentanone O-(2-Aminoethyl)oxime Maleate(917096-37-8)

Safety Data

• Hazardous Substances Data: 917096-37-8(Hazardous Substances Data)

Usage

Chemical Properties

Yellow Oil

Uses

The geometric isomer of the second-generation antidepressant Fluvoxamine.

Upstream product

• 61747-22-6 1-N-hydroxy-5-methoxy-1-[4-(trifluoromethyl)phenyl]pentan-1-imine 
• 870-24-6 2-chloroethanamine hydrochloride 
• 110-16-7 maleic acid 
• 61718-80-7 5-methoxy-1-[4-(trifluoromethyl)phenyl]pentan-1-one 
• 37866-45-8 2-aminoethoxyamine dihydrochloride 

Relevant articles and documents

AN IMPROVED PROCESS FOR THE PREPARATION OF FLUVOXAMINE MALEATE

The present invention relates to an industrially feasible and economically viable process for the preparation of fluvoxamine maleate of formula I.

Process for the preparation of fluvoxazmine maleate

A process is described for the preparation of substantially pure fluvoxamine maleate, an important antidepressant drug of the formula I, for use as an active pharmaceutical ingredient (API), from the corresponding oxime viz 5-methoxy-4′-trifluoromethylvalerophenone oxime of formula II.

Oxime ethers having anti-depressive activity

Novel 4'-trifluoromethylvalerophenone 0-(2-aminoethyl)oximes are found to exhibit a strong anti-depressive activity based on a strong serotone potentiation but with the absence of monoamino/oxidase inhibition and undesirable side effects.