Development of pyrimidine-based inhibitors of Janus tyrosine kinase 3
A new class of pyrimidine-based Janus tyrosine kinase 3 (JAK3) inhibitors are described. Many of these inhibitors showed low nanomolar activity against JAK3.
Chen, Jack J.,Thakur, Kumar D.,Clark, Michael P.,Laughlin, Steven K.,George, Kelly M.,Bookland, Roger G.,Davis, Jan R.,Cabrera, Edward J.,Easwaran, Vijay,De, Biswanath,George Zhang
p. 5633 - 5638
(2007/10/03)
Pyrimidines. Part 2. Synthesis of Imidazo- and Pyrimidopyrimidinediones