The first enantioselective total synthesis of (S)-equol is reported. The described route relies on an Evans alkylation to form the stereocenter and an intramolecular Buchwald etherification to generate the chroman ring. Key features of this method include its brevity, its scalability, and the low cost of starting materials.
Heemstra, Jennifer M.,Kerrigan, Sean A.,Doerge, Daniel R.,Helferich, William G.,Boulanger, William A.
p. 5441 - 5443
(2007/10/03)
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