917388-43-3

Basic information

• Product Name: ethyl 3-(3-methoxyphenyl)-5-methylisoxazole-4-carboxylate
• Synonyms: ethyl 3-(3-methoxyphenyl)-5-methylisoxazole-4-carboxylate
• CAS NO: 917388-43-3
• Molecular Formula: C₁₄H₁₅NO₄
• Molecular Weight: 261.2732
• Mol File: 917388-43-3.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: ethyl 3-(3-methoxyphenyl)-5-methylisoxazole-4-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 3-(3-methoxyphenyl)-5-methylisoxazole-4-carboxylate(917388-43-3)
• EPA Substance Registry System: ethyl 3-(3-methoxyphenyl)-5-methylisoxazole-4-carboxylate(917388-43-3)

Safety Data

• Hazardous Substances Data: 917388-43-3(Hazardous Substances Data)

Upstream product

• 2723-42-4 ethyl 3-pyrrolidinobut-2-enoate 
• 38489-80-4 3-methoxybenzaldehyde oxime 

Downstream Products

• 93002-09-6 3-(3-methoxy-phenyl)-5-methyl-isoxazole-4-carboxylic acid 

Relevant articles and documents

Isoxazolopyridone derivatives as allosteric metabotropic glutamate receptor 7 antagonists

This Letter describes the synthesis and evaluation of mGluR7 antagonists in the isoxazolopyridone series. In the course of modification in this class, novel solid support synthesis of the isoxazolopyridone scaffold was developed. Subsequent chemical modification led to the identification of several potent derivatives with improved physicochemical properties compared to a hit compound 1. Among these, 2 showed good oral bioavailability and brain penetrability, suggesting that 2 may be useful for in vivo study to elucidate the role of mGluR7.