Pyrrolidino-tetrahydroisoquinolines bearing pendant heterocycles as potent dual H3 antagonist and serotonin transporter inhibitors
A series of novel and potent 6-heteroaryl-pyrrolidino-tetrahydroisoquinolines with dual histamine H3 antagonist/serotonin transporter inhibitor activity is described. In vitro and in vivo data are discussed.
Keith, John M.,Gomez, Leslie A.,Barbier, Ann J.,Wilson, Sandy J.,Boggs, Jamin D.,Lord, Brian,Mazur, Curt,Aluisio, Leah,Lovenberg, Timothy W.,Carruthers, Nicholas I.
p. 4374 - 4377
(2008/02/11)
HEXAHYDRO-PYRROLO-ISOQUINOLINE COMPOUNDS
Certain hexahydro-pyrrolo-isoquinoline compounds are histamine H3 receptor and serotonin transporter modulators useful in the treatment of histamine H3 receptor- and serotonin-mediated diseases.
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Page/Page column 51
(2010/11/25)
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