- METHOD FOR PRODUCING OPTICALLY ACTIVE AMINOALKYLPHENOLS
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The invention relates to a method for the enantioselective N-acylation of aminoalkylphenols, and to a method for producing enantiomer-pure compounds of formulae (I-S) and/or (I-R).
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Page/Page column 27-28
(2008/06/13)
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- HIV PROTEASE INHIBITORS
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Peptide mimics, having a constrained peptide backbone conformation, are HIV protease inhibitors. A compound of this invention is, for example, 3-Benzyl-5(alaninyl-1-aminoethyl)-2,3,6,7-tetrahydro-N-azepinyl-2-propionyl-valinyl-valinyl methyl ester.
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- A novel constrained reduced-amide inhibitor of HIV-1 protease derived from the sequential incorporation of γ-turn mimetics into a model substrate
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C7 mimetics, designed to lock three amino acid residues of a peptide chain into a γ-turn conformation, were introduced sequentially between the P3 to P2' positions of a model HIV-1 protease substrate I (resulting in compou
- Newlander,Callahan,Moore,Tomaszek Jr.,Huffman
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p. 2321 - 2331
(2007/10/02)
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