Highly functionalized benzene syntheses by directed mono or multiple magnesiations with TMPMgCl·LiCl
The direct magnesiation of highly functionalized aromatics bearing an ester, a nitrile, or a ketone can be readily performed by using an OBoc as a directing group and TMPMgCl·LiCl as a base. It allows, for example, the preparation of a meta-magnesiated benzophenone in >95%. After quenching, highly functionalized and substituted benzenes are obtained.
Lin, Wenwei,Baron, Oliver,Knochel, Paul
p. 5673 - 5676
(2007/10/03)
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